Quercetin Solubility for Nasal Spray Formulation
Question
I would like to inquire about the solubility of Quercetin. Does Quercetin dissolve in water? If not, what solvents or solubilizers are recommended for formulating a nasal spray?
Answer
Quercetin is poorly soluble in water. For effective incorporation into formulations, especially for a nasal spray, it typically requires a suitable solvent or carrier.
Common solvents that can be used for Quercetin include:
- Ethanol
- Propylene Glycol
- Various oil-based systems (though these might be less suitable for a nasal spray depending on the specific formulation)
For enhanced solubility in aqueous solutions, such as for a nasal spray, you might consider formulating Quercetin with:
- Cyclodextrins: These can encapsulate Quercetin, improving its water solubility.
- Liposomal delivery systems: These can also help to solubilize and deliver Quercetin in aqueous environments.
Given that you are developing a nasal spray, focusing on cyclodextrins or liposomal systems, or using a combination of water with ethanol or propylene glycol as co-solvents, would be beneficial to achieve a stable and effective formulation.