Information Regarding Your Questions

Here is the information regarding your questions about product availability and ingredient usage:

1. Product Availability

Based on the staff's reply, the product you are asking about is expected to be available in Thailand by early next month.

2. Using Tranexamic Acid and Copper Peptide with TransDerm™ Transdermal Gel

Regarding the use of Tranexamic Acid and Copper Peptide with TransDerm™ Transdermal Gel for enhanced penetration:

• Tranexamic Acid: Tranexamic Acid is used in cosmetics at a maximum concentration of 3% as permitted by regulatory bodies like the FDA. This concentration is significantly lower than the doses used in oral medication for medical purposes, such as controlling bleeding after surgery. Therefore, the amount absorbed through topical cosmetic application is very small, and it is not expected to interact with the bloodstream in the same way as medicinal doses. The primary function in cosmetics is skin brightening and reducing blemishes.
• Copper Peptide: Copper Peptide (GHK-Cu) is known for its benefits in addressing scar problems, acne scars, and reducing wrinkles. Product descriptions indicate it is suitable for use with tools like Derma Rollers to stimulate skin cell regeneration and improve the appearance of scars and wrinkles. While TransDerm™ Transdermal Gel is intended to enhance penetration, the safety of cosmetic ingredients like Copper Peptide is evaluated based on their intended use and concentration limits in topical applications. The risk associated with deeper penetration within the scope of cosmetic application is generally considered low, especially compared to invasive procedures.

In summary, cosmetic formulations containing these ingredients at permitted concentrations are designed for topical use, and the potential for systemic effects is minimal compared to medicinal applications.

3. Availability of Other Ingredients

Regarding the two other ingredients you inquired about:

• Substance that absorbs oil on skin but not in formula: The staff indicated that MatteSilica is currently available for absorbing oil on the skin. Other types that were tested did not show sufficient effectiveness or were too expensive. MatteSilica works by absorbing excess oil on the skin and can also improve the texture and slip of formulations. However, it's noted that in oil-based formulas, MatteSilica might absorb oil within the formula itself, potentially reducing its effectiveness in absorbing skin oil.
• Oxyresveratol: The staff mentioned that Oxyresveratol has stability issues, making it difficult to keep stable in formulations for a long period. Product information for Artocarpus Lakoocha Wood Extract (Oxyresveratrol 98%) confirms that while it offers benefits like skin brightening and antioxidant properties, stability is a limitation. Steps such as using Sodium Metabisulphite, Disodium EDTA, antioxidants, UV protection, and maintaining a specific pH range (4-6) are recommended to help improve its stability in a formula.