Recommended Percentages and Mixing Procedure for Vitamin A Oil Gel

Based on your proposed formula and the staff's advice:

• Protect UV (Benzotriazolyl Dodecyl p-Cresol): The staff recommends using 0.1% if the packaging is translucent.
• Protect OX (Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate): Your proposed rate of 0.05% is sufficient. It works indirectly with Protect UV to slow down oxidation caused by UV light.
• Tocopheryl Acetate (Vitamin E): A concentration of 0.05% is sufficient. Higher concentrations have not been found to provide significantly better oxidation protection in the formula.

Regarding the mixing procedure, your initial proposed method is suitable:

1. Heat the oil to 70-80°C and dissolve Protect OX.
2. Dissolve the oil gelator in the oil while continuously mixing (this forms the Oil Gel base).
3. Wait for the temperature to drop below 40°C, then add Tocopheryl Acetate, Protect UV, and Retinyl Palmitate. Mix until homogeneous and cooled to room temperature.

The alternative method of mixing all liquid ingredients first and then heating is not recommended because ingredients like Tocopheryl Acetate and Retinyl Palmitate are sensitive to direct heat, even for short periods at 80°C. While short exposure might not cause significant degradation, avoiding direct heating of these sensitive components is preferable for maintaining quality.

For large-scale production, the staff suggests moving the gelation step (step 2) to the final stage to save mixing energy.