Review and Mixing Instructions for Three Serum Formulations

ถามโดย: suphap_1978 เมื่อ: April 26, 2018 ประเภทผลิตภัณฑ์: เครื่องสำอาง

คำถาม

I am planning to formulate three different serums and would like your review on the ingredient compatibility and mixing instructions for each. Please advise if the ingredients can be mixed together and how to mix them.

1. Face Serum

  • Skin type: Oily with slight freckles, slightly enlarged pores, and occasional acne (no topical acne medication used).
  • Ingredients:
    1. Willow Bark Extract (Natural Salicylic Acid) 5%
    2. Licorice Extract 1%
    3. French Pine Bark Extract 25 (Liquid) 1%
    4. Chamomile Extract (Apigenin) 1%
    5. Magnolia Extract 1%
    6. Double Hyaluron 1%
    7. Glycerin (Vegetable) 1%
    8. Safe-B3 4%
    9. GlucoBright 3%
    10. Pro Polymer 0.5%
    11. Butylene Glycol 1%
    12. Mild Preserved Eco 0.5%
    13. Purified Water (rest)

2. Eye Serum

  • Ingredients:
    1. Boswellia Serrata Extract (Boswellic Acid) 1%
    2. Butylene Glycol 6%
    3. Safe-B3 1%
    4. GlucoBright 1%
    5. Pro Polymer 0.5%
    6. Butylene Glycoi 0.5%
    7. Mild Preserved Eco 0.5%
    8. Purified Water (rest)

3. Anti-Wrinkle Serum

  • Skin type: Facial skin with crow's feet, forehead wrinkles, and dehydrated skin.
  • Ingredients:
    1. Acetyl Hexapeptide-8 (Argire line) 3%
    2. Pep-Coll 3%
    3. DMAE (skin Tight-MD) 5%
    4. Safe-B3 3%
    5. ClucoBright 2%
    6. Pro Polymer 0.5%
    7. Butylene Glycol 1%
    8. Mild Preserved Eco 0.5%
    9. Purified Water (rest)

คำตอบ

Serum Formulations Review

Overall, the ingredients you have chosen for each serum formulation are generally compatible and target the skin concerns you've described. However, attention to mixing order, temperature, and pH is crucial for stability and effectiveness.

Face Serum for Oily Skin with Freckles, Pores, and Occasional Acne

This formulation includes ingredients targeting exfoliation (Willow Bark Extract), anti-inflammation and oil control (Licorice Extract, Safe-B3™), antioxidant protection (French Pine Bark Extract), soothing (Chamomile Extract, Magnolia Extract), hydration (Double Hyaluron Liquid, Glycerin), brightening (Safe-B3™, GlucoBright™), and thickening (Pro Polymer™).

Compatibility: The ingredients are generally compatible. The pH range required for optimal activity and stability of the extracts (Willow Bark, Licorice, Chamomile) and Niacinamide (Safe-B3™) overlaps well within the 4.0-6.5 range. GlucoBright™ is also stable in this range. Pro Polymer™ can be sensitive to electrolytes, which are present in some extracts and active ingredients. Using 0.5% Pro Polymer™ might result in a less viscous gel or potential thinning if the electrolyte concentration is high.

Mixing Instructions:

  1. In a beaker, combine Purified Water, Butylene Glycol, Glycerin, and Double Hyaluron Liquid. Stir until homogenous.
  2. Add Safe-B3™ and GlucoBright™ to the water mixture and stir until completely dissolved.
  3. Slowly sprinkle Pro Polymer™ powder onto the surface of the liquid while stirring gently. Continue stirring slowly until the powder is fully dispersed and begins to hydrate. Avoid high-speed blending at this stage to prevent damaging the polymer structure. Allow sufficient time for the polymer to hydrate and the gel to form (this may take some time).
  4. Once a smooth gel is formed, add Willow Bark Extract, Licorice Extract, French Pine Bark Extract, Chamomile Extract, and Magnolia Extract. Stir gently to incorporate. Ensure the temperature of the mixture is below 40°C when adding these extracts.
  5. Add Mild Preserved Eco™ and stir until evenly distributed.
  6. Check the pH of the final serum. Adjust if necessary to be within the 4.0-6.5 range for optimal ingredient performance.

Eye Serum

This formulation focuses on reducing irritation (Boswellia Serrata Extract), hydration (Butylene Glycol, GlucoBright™), and potentially dark circles (Safe-B3™).

Compatibility: The ingredients are generally compatible. Safe-B3™ and GlucoBright™ are compatible and beneficial for the eye area. Boswellia Serrata Extract is noted as soluble in Propylene Glycol, while your formula uses Butylene Glycol. While similar, solubility might differ. You may need to pre-disperse or attempt to dissolve the Boswellia Serrata Extract in the Butylene Glycol portion before adding to the water phase. The pH range of 4.0-6.5 is suitable for Boswellia Serrata Extract and Safe-B3™. Pro Polymer™ at 0.5% is used for thickening.

Mixing Instructions:

  1. In a beaker, combine Purified Water and Butylene Glycol (total 6.5%). Stir until homogenous.
  2. Add Safe-B3™ and GlucoBright™ to the water mixture and stir until completely dissolved.
  3. Slowly sprinkle Pro Polymer™ powder onto the surface of the liquid while stirring gently. Continue stirring slowly until dispersed and hydrating. Allow time for gel formation.
  4. While the gel is forming, attempt to dissolve or disperse the Boswellia Serrata Extract in a small portion of the Butylene Glycol/Water mixture. Add this to the main batch once the gel is formed. Stir gently to incorporate. Ensure the temperature is below 40°C.
  5. Add Mild Preserved Eco™ and stir until evenly distributed.
  6. Check the pH and adjust if needed to be within the 4.0-6.5 range.

Anti-Wrinkle Serum

This formulation combines peptides (Acetyl Hexapeptide-8, Pep-Coll) for wrinkle reduction and collagen stimulation, DMAE for skin tightening, Safe-B3™ and GlucoBright™ for various benefits including brightening and hydration, and thickeners/solvents.

Compatibility: The peptides (Acetyl Hexapeptide-8, Pep-Coll) and DMAE are generally compatible with the other ingredients. Acetyl Hexapeptide-8 requires a pH of 3.5-6.5, which aligns well with the optimal pH for Safe-B3™ (4.0-7.0) and GlucoBright™ (3-7). Mild Preserved Eco™ is also compatible in this range. DMAE at 5% is at the higher end of the recommended usage rate and may cause irritation, especially on dry/dehydrated skin. Consider adding an anti-irritant ingredient to the formulation. Pro Polymer™ at 0.5% is used for thickening.

Mixing Instructions:

  1. In a beaker, combine Purified Water and Butylene Glycol. Stir until homogenous.
  2. Add Safe-B3™ and GlucoBright™ to the water mixture and stir until completely dissolved.
  3. Slowly sprinkle Pro Polymer™ powder onto the surface of the liquid while stirring gently. Continue stirring slowly until dispersed and hydrating. Allow time for gel formation.
  4. Once a smooth gel is formed, add Acetyl Hexapeptide-8, Pep-Coll, and DMAE. Stir gently to incorporate. Ensure the temperature is below 40°C.
  5. Add Mild Preserved Eco™ and stir until evenly distributed.
  6. Check the pH and adjust if needed to be within the 4.0-6.5 range. Consider adding an anti-irritant ingredient if you find the 5% DMAE irritating.

ผลิตภัณฑ์ที่เกี่ยวข้องที่กล่าวถึง

Acetyl Hexapeptide-8 (eq Argireline)
Acetyl Hexapeptide-8 (eq Argireline)
เครื่องสำอาง
Pep®-Coll (Palmitoyl tripeptide-5)
Pep®-Coll (Palmitoyl tripeptide-5)
เครื่องสำอาง
Licorice Extract (Licochalcone A 1%, Water-Soluble)
Licorice Extract (Licochalcone A 1%, Water-Soluble)
เครื่องสำอาง
Safe-B3™ (Vitamin B3, Niacinamide)
Safe-B3™ (Vitamin B3, Niacinamide)
เครื่องสำอาง
GlucoBright™ (Acetyl Glucosamine)
GlucoBright™ (Acetyl Glucosamine)
เครื่องสำอาง
Glycerin (USP/Food Grade)
Glycerin (USP/Food Grade)
เครื่องสำอาง
Pro Polymer™ (Gel Maker)
Pro Polymer™ (Gel Maker)
เครื่องสำอาง
Butylene Glycol
Butylene Glycol
เครื่องสำอาง
Double Hyaluron Liquid
Double Hyaluron Liquid
เครื่องสำอาง
DMAE (SkinTight MD™) Liquid
DMAE (SkinTight MD™) Liquid
เครื่องสำอาง
Purified Water, TDS Limit 1PPM)
Purified Water, TDS Limit 1PPM)
เครื่องสำอาง
Magnolia Extract (Magnolol, Honokiol)
Magnolia Extract (Magnolol, Honokiol)
เครื่องสำอาง
Mild Preserved Eco™ (Preservative-Free)
Mild Preserved Eco™ (Preservative-Free)
เครื่องสำอาง
Boswellia Serrata Extract (Boswellic Acid)
Boswellia Serrata Extract (Boswellic Acid)
เครื่องสำอาง
Willow Bark Extract (Natural Salicylic Acid)
Willow Bark Extract (Natural Salicylic Acid)
เครื่องสำอาง
Chamomile Extract (Apigenin)
Chamomile Extract (Apigenin)
เครื่องสำอาง