Review of Your Anti-Wrinkle Gel Formulation

Your formulation includes a comprehensive blend of active ingredients targeting wrinkles and skin firmness. Here's a review of the components and percentages you've chosen:

Ingredients and Percentages

• Lift-Now™ (5%): This is within the recommended range and is great for providing an immediate, temporary skin tightening effect. Best used in a product applied during the day.
• Repair Activator™ BG (5%): This percentage is well within the recommended range and helps with skin DNA repair, particularly from UVA damage.
• Wrinkle-Fill™ (2%): You are using the maximum recommended percentage, which is good for maximizing its effects on firmness, GAGs, and collagen, especially in combination with DMAE.
• DMAE Liquid (3%): This is at the recommended percentage. DMAE is known for its skin tightening and anti-wrinkle properties and works synergistically with Vitamin B5 and peptides like Wrinkle-Fill. Be mindful that higher concentrations can cause irritation, but 3% is generally well-tolerated.
• Panthenol (Vitamin B5) (3%): This is at the higher end of the recommended range (1-3% recommended, up to 10%). It's excellent for hydration, soothing, and supporting skin healing, and it works synergistically with DMAE. Note that at 3%, it might contribute slightly to a sticky feel.
• Adenosine Liposome (3%): This is at the recommended percentage and is beneficial for reducing wrinkles and supporting skin cell function.
• WaterLock™ (2%): This is at the recommended percentage for dry skin and helps prevent moisture loss and can reduce potential irritation.
• Xanthan Gum (1%): This is the recommended percentage for thickening and creating a clear gel texture.
• Preservative (1%): Essential for preventing microbial growth.
• Water (75%): The base of your gel.

Overall Assessment and Suggestions

Your selection of active ingredients is excellent for targeting multiple signs of aging, providing both immediate (Lift-Now) and long-term benefits. The percentages chosen are generally appropriate based on the product descriptions.

Here are a few points to consider:

• pH Level: Some ingredients like Wrinkle-Fill are acidic. You should check the final pH of your gel and adjust it to be within a skin-friendly range (typically 4.5-6.5) and suitable for the stability and efficacy of all ingredients, including your chosen preservative.
• Preservation: Ensure the preservative you are using is effective at the final pH of your formulation and provides broad-spectrum protection.
• Mixing Procedure: Pay attention to the mixing instructions for each ingredient. Add heat-sensitive ingredients like Repair Activator and DMAE when the gel has cooled below 40°C. Ensure Xanthan Gum is properly dispersed to avoid clumps. Adenosine Liposome should be dispersed in the water phase.
• Storage: Repair Activator, Wrinkle-Fill, and Adenosine Liposome are recommended for refrigeration for long-term storage. The final gel formulation may also benefit from refrigeration to maintain the potency of these sensitive actives, although room temperature storage might be acceptable depending on the overall stability and preservative system.
• Texture: With 1% Xanthan Gum and 3% Panthenol, test the texture. If it feels too sticky, you could slightly reduce the Xanthan Gum or Panthenol percentage, or consider adding a small amount of a slip modifier, though WaterLock already helps with this.

This looks like a potent anti-wrinkle gel formulation. By paying attention to pH, preservation, and mixing techniques, you should be able to create an effective product.