Safety of Ethoxydiglycol Concentration

Ethoxydiglycol is widely used in cosmetics as a solvent and, importantly, as a penetration enhancer. This means it helps other ingredients in the formula absorb into the skin more effectively.

Regulatory bodies like the FDA (อย.) set concentration limits for cosmetic ingredients based on safety assessments. These limits consider factors such as potential skin irritation, sensitization, and the ability of the ingredient to increase the absorption of other substances, which could potentially lead to adverse effects if absorbed in excessive amounts.

The information available indicates that the current recommended usage rates for high-purity cosmetic grade Ethoxydiglycol are significantly lower than 20%:

• Not more than 2.6% for leave-on or skin spray products.
• Not more than 5% for non-oxidative hair coloring products.
• Not more than 7% for oxidative hair coloring products.
• Not more than 10% for rinse-off products (like shampoo or soap).

While Ethoxydiglycol itself is considered safe at appropriate concentrations and purity levels, using it at a high concentration like 20% would exceed the recommended safety limits for most cosmetic applications. Exceeding these limits could potentially lead to:

• Increased risk of skin irritation or sensitization, especially if the grade used is not of high purity.
• Enhanced absorption of other ingredients in the formula, which might be harmful if they penetrate the skin too deeply or in higher concentrations than intended.

Therefore, even though the substance itself may have low inherent toxicity, its function as a penetration enhancer and potential for irritation at high levels are key reasons for the regulatory limits. Adhering to the recommended usage rates is crucial for ensuring the safety and compliance of cosmetic products.