Serum Formulation Analysis and Adjustment

Thank you for your inquiry regarding your serum formulation. Let's analyze the proposed formula and provide some recommendations.

1. Feasibility Analysis

The proposed formula contains a high concentration of various active ingredients:

• Pitera: 60%
• Repair Activator: 10%
• Argireline: 10%
• Matrixyl 3000: 8%
• Glycerin Gel: 5%
• Adenosine Liposome: 4%
• Copper Peptide: 3%

The total percentage of these ingredients is 100%. A typical serum formulation requires water as the primary solvent, along with a preservative system and potentially pH adjusters. As written, this formula does not include water or a preservative, making it unfeasible to manufacture as a stable serum.

Additionally, some ingredients are included at concentrations higher than typically recommended for optimal efficacy and stability:

• Matrixyl 3000 is recommended for use at 3-5%, while the proposed formula uses 8%.
• Adenosine (assuming Pure-Adenosine) is typically used at 0.1-1.0%, while the proposed formula includes 4% of "Adenosine Liposome". If this refers to Pure-Adenosine, 4% is significantly higher than recommended. If it refers to a liposomal product, the recommended usage rate is also typically lower than 4%.

The high total concentration of active ingredients (100%) without a solvent base like water will result in a product that is not a serum texture and is likely unstable.

2. Formula Adjustment Recommendations

To create a feasible and stable serum, the formula needs significant adjustment. The concentrations of the active ingredients should be reduced to their recommended usage rates, and water, a preservative, and a pH adjuster must be included.

Here is an example of how the formula could be adjusted to be more feasible, using recommended maximum usage rates for most actives and including necessary base components:

• Pitera: 10-20% (Adjust based on desired efficacy and overall formula balance)
• Repair Activator: 10%
• Argireline: 10%
• Matrixyl 3000: 3-5% (Recommended 3%)
• Pure-Adenosine: 0.5-1.0% (Assuming Pure-Adenosine is used)
• Copper Peptide: 1-3%
• Glycerin Gel: 5-10% (Adjust based on desired texture)
• Preservative: As needed (Choose a suitable broad-spectrum system)
• Water: Balance to 100%
• pH Adjuster: As needed (To achieve a final pH between 4.5 and 6.5 for optimal stability of all actives, especially Copper Peptide).

This adjusted formula provides a starting point. The exact percentages and compatibility would need to be confirmed through laboratory testing.

3. Shelf Life

For a serum formulated with these ingredients and a proper preservative system:

• Unopened (stored in the refrigerator): If stored correctly in the refrigerator (4-8°C) and unopened, the serum could have a shelf life of approximately 12-24 months, depending on the specific ingredients and preservative system used.
• After Opening: Once opened, the product is exposed to air and potential contamination, which reduces its shelf life. If stored in the refrigerator after opening, it is generally recommended to use the serum within 6-12 months for best quality and safety. Proper hygiene during use (e.g., using a dropper without touching the skin) can help extend the opened shelf life.

Please note that these are general guidelines. The actual shelf life of the finished product should be determined through stability testing.