Serum Formulation Ingredients

Here is an analysis of the ingredients in your serum formulation:

• Water (น้ำกลั่น and น้ำ): These are standard components in water-based serums and are not considered dangerous.
• EDTA (Disodium EDTA): Used as a chelating agent to improve stability. Disodium EDTA is generally considered safe for cosmetic use at recommended concentrations.
• Allantoin: Known for its soothing and anti-irritant properties. It is considered safe and suitable even for sensitive skin.
• Hyaluronic Acid (Hyaluronic Acid and Double Hyaluron liquid): A common moisturizing ingredient. Different molecular weights (Standard, Large, Super Low Molecule) provide hydration at various levels of the skin. It is considered safe.
• Glycerin: A widely used humectant that helps retain moisture in the skin. It is safe for cosmetic use.
• Butylene Glycol: Acts as a solvent and humectant, often used as a gentler alternative to Propylene Glycol. It is considered safe.
• Vitamin B3 (Niacinamide): Beneficial for reducing wrinkles, hyperpigmentation, and oiliness. The Safe-B3™ type is noted for its high purity and reduced flushing. Generally safe, but high concentrations might cause temporary redness in some individuals.
• Vitamin B5 (Panthenol): A moisturizer and skin-conditioning agent. PreB5™ is a precursor. Vitamin B5 is considered safe.
• NANO WHITE: We could not find specific information on a product named "NANO WHITE" in our database. Please ensure you have detailed information about this ingredient.
• Vitamin C (L-ascorbic acid) (Ultra-Fine): A potent antioxidant and skin brightener. L-ascorbic acid is effective but can be unstable when dissolved in water and requires careful formulation within a specific pH range (ideally 3.5-4.0 for leave-on products) to maintain stability and efficacy. While not inherently dangerous, improper formulation can lead to reduced effectiveness or potential irritation due to pH.
• DMAE (Dimethylaminoethanol): Used for skin firming and reducing wrinkles. The description for DMAE (SkinTight MD™) Liquid notes that it might not be suitable for thin, sensitive skin and can cause irritation at high concentrations. It is recommended to start with a lower concentration (e.g., 3% as in your formula) and consider adding irritation-reducing ingredients if you have sensitive skin.
• Thyme Care™ (natural preservative): A natural preservative derived from Thyme and Bois De Rose. It is used to prevent microbial growth in the formulation.

Preservative Substitution: Thyme Care™ vs. Global Guard™

You asked if Global Guard™ can be used instead of Thyme Care™. Based on the product information:

• Global Guard™ (Product ID 879): The description for this preservative explicitly states: "Warning: Do not use Global Guard™ with any formulation of Vitamin C in the formula." Since your serum formulation contains Vitamin C (L-ascorbic acid), Global Guard™ (Product ID 879) is not suitable for use as it can interfere with Vitamin C.
• Global Guard™ 221 (Product ID 33554): This is another type of Global Guard preservative. Its description does not mention incompatibility with Vitamin C and states it can be used in formulas with a pH between 2-7. Based on this information, Global Guard™ 221 might be a possible alternative, but it is highly recommended to perform a challenge test to confirm its effectiveness and compatibility with your specific formula before production and distribution.

In summary, while most ingredients in your serum formulation are commonly used and considered safe, be mindful of the potential for irritation with DMAE on sensitive skin and the specific pH and stability requirements for Vitamin C. Global Guard™ (Product ID 879) should not be used due to the presence of Vitamin C; Global Guard™ 221 (Product ID 33554) may be an alternative, but testing is crucial.