Serum Formulation with AA2G and HEC

Here is a sample formulation for a brightening serum using Ascorbyl Glucoside (AA2G) in a Hydroxyethyl Cellulose (HEC) base, designed to be non-drying and suitable for sensitive skin.

Key Considerations:

• Ascorbyl Glucoside (AA2G) is most stable at a pH between 6.5 and 6.8. It is crucial to adjust the final serum pH to this range.
• Hydroxyethyl Cellulose (HEC) requires heating to approximately 70°C to dissolve and form a gel.

Sample Formulation Structure:

• Phase A (Water Phase):

  • Water (Distilled/Deionized): ~70-80%
  • Hydroxyethyl Cellulose (HEC): 0.5-1.5% (adjust for desired viscosity)
  • Glycerin: 3-5% (for hydration)
  • Mild Preserved™ COS: 1% (broad-spectrum preservative)

• Phase B (Active Phase):

  • Ascorbyl Glucoside (AA2G): 2-10% (choose desired concentration)
  • Water (small amount from Phase A water): To dissolve AA2G
  • Citrate Buffer or L-Arginine: As recommended for AA2G dissolution/pH control (refer to AA2G product details)
  • pH Adjuster (e.g., Triethanolamine or Sodium Hydroxide solution): As needed to reach pH 6.5-6.8

Preparation Steps:

1. Prepare Phase A: Heat the main portion of the water to 70°C. Slowly add Hydroxyethyl Cellulose (HEC) while stirring continuously until a uniform gel forms. Let the gel cool down.
2. Once cooled, add Glycerin and Mild Preserved™ COS to the HEC gel base. Stir thoroughly until all ingredients are evenly dispersed.
3. Prepare Phase B: In a separate container, dissolve the Ascorbyl Glucoside (AA2G) in a small amount of water (taken from the total water amount in Phase A). If using, add Citrate Buffer or L-Arginine as recommended by the AA2G product instructions.
4. Measure the pH of the AA2G solution. Carefully add a pH adjuster (such as a dilute solution of Triethanolamine or Sodium Hydroxide) drop by drop, stirring and re-measuring the pH until it reaches the target range of 6.5-6.8.
5. Combine Phases: Slowly add the pH-adjusted AA2G solution (Phase B) to the HEC gel base (Phase A) while stirring continuously. Continue stirring until the entire serum is homogenous and clear.
6. Final Check: Measure the pH of the final serum to ensure it is within the stable range of 6.5-6.8. Adjust slightly if necessary.

This formulation provides the brightening benefits of AA2G with a hydrating and non-irritating base from HEC and Glycerin, preserved effectively with Mild Preserved™ COS.