Formulation Review

Based on the ingredients and percentages provided, this serum formulation appears technically mixable. The percentages for each ingredient are within the recommended usage rates according to their product descriptions.

Key Considerations:

• High Concentration of Actives: This formula contains a high combined concentration of several potent active ingredients (DMAE, Snow Algae, Wrinkle-Lax, Pep®-Coll, and Acetyl Octapeptide-3). While each is within its individual recommended range, combining them at these levels could increase the risk of skin irritation or sensitivity, especially for individuals with sensitive skin. DMAE, in particular, is noted for potential irritation at higher concentrations.
• Mixing Order: A suggested mixing order would be:
  1. Combine Distilled Water and Propanediol.
  2. Properly disperse and hydrate the Pro Polymer in the water/propanediol mixture to form the gel base. (Pre-mixing Pro Polymer with Propanediol before adding water might aid dissolution).
  3. Once the gel base is formed and cooled to below 40°C, gently add the heat-sensitive active ingredients one by one: DMAE, Snow Algae, Wrinkle-Lax, Pep®-Coll, Acetyl Octapeptide-3, and Probio-Protect. Mix gently after each addition until fully incorporated.
• Stability: With a high concentration of various active ingredients, the long-term stability of the final product (color, clarity, viscosity, efficacy) should be carefully monitored.

Recommendation:

The formulation can likely be mixed as proposed. However, due to the high concentration of active ingredients, it is strongly recommended to perform a small test batch first to check for stability and any signs of incompatibility. If you have sensitive skin or experience irritation, you may need to reduce the concentration of some active ingredients, particularly DMAE, or consider adding soothing agents to the formula. Performing a challenge test is crucial to ensure the preservative system is effective in the final product.