Serum Formulation with Multiple Active Ingredients

Question

I want to order a serum product. I need all these ingredients in the product. Please provide advice. ([url=https://www.myskinrecipes.com/shop/anti-wrinkle/7360-sheep-placenta-%E0%B8%A3%E0%B8%81%E0%B9%81%E0%B8%8ก%E0%B8%B0%E0%B8%ส%E0%B8%ก%E0%B8%ั%E0%B8%ด-hydrolyzed-placental-extract.html:ugifix4q]Hydrolyzed Placental Extract[/url:ugifix4q], Powder 99% Purity) ,(Syn-Ake eq.) [url=https://www.myskinrecipes.com/shop/%E0%B8%ย%E0%B8%ก%E0%B8%ก%E0%B8%ร%E0%B8%ะ%E0%B8%ช%E0%B8%B1%E0%B8%บ%E0%B8%ผ%E0%B8%B4%E0%B8%ว/7284-syn-ake-dipeptide-diaminobutyroyl-benzylamide-diacetate.html:ugifix4q]Dipeptide Diaminobutyroyl Benzylamide Diacetate[/url:ugifix4q], [url=https://www.myskinrecipes.com/shop/anti-wrinkle/7385-pro-xylane.html:ugifix4q]Hydroxypropyl Tetrahydropyrantriol (eq. Pro-Xylane)[/url:ugifix4q],[url=https://www.myskinrecipes.com/shop/anti-wrinkle/7361-sodium-copper-chlorophyllin-complex.html:ugifix4q]Sodium Copper Chlorophyllin Complex[/url:ugifix4q],[url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/1298-alpha-arbutin-%E0%B8%อ%E0%B8%ั%E0%B8%ล%E0%B8%ฟ%E0%B9%88%E0%B8%า%E0%B8%อ%E0%B8%B2%E0%B8%ร%E0%B9%8์%E0%B8%บ%E0%B8%B9%E0%B8%ต%E0%B8%ิ%E0%B8%น-%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว%E0%B9%83%E0%B8%ส%E0%B8%อ%E0%B8%ย%E0%B9%88%E0%B8%า%E0%B8%ง%E0%B8%ป%E0%B8%ล%E0%B8%อ%E0%B8%ด%E0%B8%ภ%E0%B8%B1%E0%B8%ย.html:ugifix4q]Deoxyarbutin (D-Arbutin)[/url:ugifix4q],[url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/699-sepiwhite-msh-undecylenoyl-phenylalanine.html:ugifix4q]MSH White™[/url:ugifix4q] [url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ล%E0%B8%B0%E0%B8%ล%E0%B8%B2%E0%B8%ย%E0%B9%83%E0%B8%น%E0%B9%89%E0%B8%B3/7348-z-white-zinc-glycinate.html:ugifix4q]Z-White™[/url:ugifix4q],[url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/1213-4msk-potassium-methoxysalicylate.html:ugifix4q]4MSK (Potassium Methoxysalicylate)[/url:ugifix4q] ,[url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/147-%E0%B8%ก%E0%B8%ร%E0%B8%ด%E0%B9%82%E0%B8%ก%E0%B8%จ%E0%B8%ิ%E0%B8%ก-kojic-acid-dipalmitate.html:ugifix4q]Kojic Acid[/url:ugifix4q],[url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/1502-licorice-extract-glabridin-90.html:ugifix4q]Licorice Extract (Glabridin 90%)[/url:ugifix4q] [url=http://www.myskinrecipes.com/shop/%E0%B8%ต%E0%B9%88%E0%B8%อ%E0%B8%ต%E0%B9%89%E0%B8%า%E0%B8%น%E0%B8%ร%E0%B8%ิ%E0%B9%89%E0%B8%ว%E0%B8%ร%E0%B8%อ%E0%B8%ย/74-vitamin-b3-niacinamide-%E0%B8%ว%E0%B8%ิ%E0%B8%ต%E0%B8%B2%E0%B8%ม%E0%B8%B4%E0%B8%น%E0%B8%บ%E0%B8%B53.html:ugifix4q]Vitamin B3[/url:ugifix4q],[url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/1140-tranexamic-acid-%E0%B8%ท%E0%B8%ร%E0%B8%B2%E0%B9%80%E0%B8%น%E0%B9%80%E0%B8%ซ%E0%B8%B2%E0%B8%ม%E0%B8%ิ%E0%B8%ค-%E0%B9%81%E0%B8%อ%E0%B8%ซ%E0%B8%ิ%E0%B8%ด.html:ugifix4q]Tranexamic Acid[/url:ugifix4q] ,[url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/116-glucosamine-n-acetyl-%E0%B8%ก%E0%B8%ล%E0%B8%B9%E0%B9%82%E0%B8%ค%E0%B8%ซ%E0%B8%B2%E0%B8%ม%E0%B8%B5%E0%B8%น.html:ugifix4q]GlucoBright™[/url:ugifix4q] ([url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/116-glucosamine-n-acetyl-%E0%B8%ก%E0%B8%ล%E0%B8%B9%E0%B9%82%E0%B8%ค%E0%B8%ซ%E0%B8%B2%E0%B8%ม%E0%B8%B5%E0%B8%น.html:ugifix4q]Acetyl glucosamine[/url:ugifix4q]),[url=https://www.myskinrecipes.com/shop/anti-wrinkle/7362-bio-mineral-fermented.html:ugifix4q]Bio-Mineral™ (Fermented Si+Mg+Cu+Fe+Zn)[/url:ugifix4q],[url=https://www.myskinrecipes.com/shop/non-silicone-emollient/7083-lactobacillus-eriodictyon-californicum-ferment-extract.html:ugifix4q]Yerba Santa Glycoprotein (Natural Silicone)[/url:ugifix4q][url=http://www.myskinrecipes.com/shop/%E0%B8%ค%E0%B8%A7%E0%B8%B2%E0%B8%ม%E0%B8%ช%E0%B8%B8%E0%B9%88%E0%B8%ม%E0%B8%ช%E0%B8%B7%E0%B9%89%E0%B8%น%E0%B8%ผ%E0%B8%B4%E0%B8%ว-moisturizer/7358-peg-ppg-14-7-dimethyl-ether.html:ugifix4q]VersaMoist™ (PEG/​PPG-14/​7 Dimethyl Ether)[/url:ugifix4q],[url=http://www.myskinrecipes.com/shop/%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B8%ส%E0%B8%ก%E0%B8%ั%E0%B8%ด%E0%B8%จ%E0%B8%า%E0%B8%ก%E0%B8%ท%E0%B8%ะ%E0%B9%80%E0%B8%ล/7080-black-caviar-extract-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B8%ส%E0%B8%ก%E0%B8%ั%E0%B8%ด%E0%B9%84%E0%B8%ข%E0%B9%88%E0%B8%ป%E0%B8%ล%E0%B8%B2%E0%B8%ค%E0%B8%า%E0%B9%80%E0%B8%ว%E0%B8%B5%E0%B8%A2%E0%B8%a3%E0%B9%8์%E0%B8%ส%E0%B8%B5%E0%B8%ด%E0%B8%B3.html:ugifix4q]Black Caviar Extract[/url:ugifix4q],[url=http://www.myskinrecipes.com/shop/%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B8%ส%E0%B8%ก%E0%B8%ั%E0%B8%ด%E0%B8%จ%E0%B8%า%E0%B8%ก%E0%B8%ท%E0%B8%ะ%E0%B9%80%E0%B8%ล/7081-white-caviar-extract-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B8%ส%E0%B8%ก%E0%B8%ั%E0%B8%ด%E0%B9%84%E0%B8%ข%E0%B9%88%E0%B8%ป%E0%B8%ล%E0%B8%B2%E0%B8%ค%E0%B8%า%E0%B9%80%E0%B8%ว%E0%B8%B5%E0%B8%A2%E0%B8%a3%E0%B9%8์%E0%B8%ส%E0%B8%B5%E0%B8%ข%E0%B8%B2%E0%B8%ว.html:ugifix4q]White Caviar Extract[/url:ugifix4q],[url=http://www.myskinrecipes.com/shop/whitening-%E0%B8%ส%E0%B8%B2%E0%B8%ร%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ผ%E0%B8%B4%E0%B8%ว%E0%B8%ข%E0%B8%B2%E0%B8%ว/1199-yeast-radiance-%E0%B9%83%E0%B8%ห%E0%B9%89%E0%B8%ค%E0%B8%ว%E0%B8%B2%E0%B8%ม%E0%B8%ก%E0%B8%ร%E0%B8%ะ%E0%B8%จ%E0%B9%88%E0%B8%า%E0%B8%ง%E0%B9%83%E0%B8%ส%E0%B9%81%E0%B8%ก%E0%B9%88%E0%B8%ผ%E0%B8%B4%E0%B8%ว.html:ugifix4q]Yeast Radiance™[/url:ugifix4q]

MySkinRecipes Expert · Accepted Answer

Serum Formulation with Multiple Actives

Thank you for providing the list of ingredients you wish to include in your serum formulation. This list contains a wide range of active ingredients targeting anti-aging, whitening, and moisturizing benefits.

Here are the ingredients you listed:

Sheep Placenta (Hydrolyzed Placental Extract)
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake eq.)
Hydroxypropyl Tetrahydropyrantriol (eq. Pro-Xylane)
Sodium Copper Chlorophyllin Complex
Deoxyarbutin (D-Arbutin)
MSH White™ (Undecylenoyl phenylalanine)
Z-White™ (Zinc Glycinate)
4MSK (Potassium Methoxysalicylate)
Kojic Acid Dipalmitate
Licorice Extract (Glabridin 90%)
Vitamin B3 (Safe-B3™, Niacinamide)
Tranexamic Acid (Trans-White™)
GlucoBright™ (Acetyl Glucosamine)
Bio-Mineral™ (Fermented Si+Mg+Cu+Fe+Zn)
Yerba Santa Glycoprotein (Natural Silicone)
VersaMoist™ (PEG/PPG-14/7 Dimethyl Ether)
Black Caviar Extract
White Caviar Extract
Yeast Radiance™

Challenges in Formulation:

Combining such a large and diverse group of active ingredients into a single stable and effective serum is a complex task due to several factors:

Solubility: Ingredients have different solubility requirements (water-soluble, oil-soluble, solvent-soluble).
Temperature Sensitivity: Many ingredients are sensitive to heat, while some require heat for dissolution.
pH Compatibility: The optimal pH ranges for stability and efficacy vary among the ingredients.
Ingredient Compatibility: Specific incompatibilities exist, such as Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake) with certain preservatives and other substances.
Stability: Some ingredients require specific stabilizers.
High Active Load: A high concentration of various actives can increase the risk of irritation.
Preservation: Animal-derived ingredients like Sheep Placenta require robust preservation, which must be compatible with other ingredients.

General Formulation Approach:

A typical approach would involve creating separate phases (water, oil, solvent for Glabridin), carefully managing temperatures during mixing, combining phases with an emulsifier, adding heat-sensitive ingredients during the cool-down phase, adjusting pH to a suitable range (ideally 4.0-6.0), and incorporating a compatible preservative system.

Recommendation:

While it is technically possible to include all these ingredients, formulating a stable, effective, and non-irritating serum is challenging. It might be more beneficial to create multiple targeted serums, each focusing on a smaller, synergistic group of actives. If you proceed with combining all, extensive stability and preservation testing will be necessary.