Skincare Formulation Advice for Mature, Sensitive Skin

Based on your questions and the previous discussion, here is a summary of the formulation advice for your skin type (normal, sensitive, with wrinkles and uneven tone) and your specific questions:

Peptide vs. DMAE

It is recommended to choose between using DMAE or peptides in your formula. Mixing them is not advised if you want to clearly evaluate the effectiveness of each ingredient on your skin.

Peptide Formulation

If you opt for a peptide-focused formula, the suggested ingredients and concentrations for mature skin are:

• Hyaluron Base
• Nano White 5%
• Delentigo 5%
• Vitamin B3 2%
• Amino Acid 3%
• Vitamin B5 3%
• Kinetin 0.1%
• Matrixyl 3000 8% (increased from 5% for mature skin)
• Argireline 10%

Adding multiple active ingredients, especially at higher concentrations and in a gel base like Hyaluron Base or Aloe Vera Gel Base, can potentially lead to a sticky or heavy texture. This might make the product more suitable for nighttime use.

• Argireline (Acetyl Hexapeptide-8) is primarily used to reduce the appearance of existing wrinkles caused by muscle movement, particularly on the forehead and around the eyes.
• Matrixyl 3000 (Pal-GHK, Pal-GQPR) helps stimulate collagen synthesis and improve skin elasticity, addressing wrinkles and promoting overall skin youthfulness. It is recommended for preventing and delaying wrinkles, and can be used alone if wrinkles are not yet present.

MSM in BHA Toner

Yes, Pure MSM can be added to a BHA (Salicylic Acid) Time Release Toner. It can help control oiliness and provides exfoliation at concentrations above 3%. Adding Zinc PCA is also suitable for oily skin to help reduce oil production and accelerate acne scar healing.

Kinetin Availability and Mixing

According to the previous reply, Kinetin was available for sale from October 14, 2013. For current availability, please check with staff.

Regarding mixing, Kinetin can be added to a base like Aloe Vera Gel Base, which may have sufficient viscosity. However, adding Kinetin later to a liquid Hyaluron Base is not recommended as it may not dissolve properly and could precipitate. Be mindful that incorporating many ingredients into a gel base can still result in a sticky texture.

Adding Tranexamic Acid

Tranexamic Acid can be added to the peptide formula to help address melasma and uneven skin tone. It is water-soluble and can be added later to a pre-mixed base. Using a nano-emulsified version like Nano-TXA may offer improved skin penetration.