Skincare Formulation for Mature, Combination Skin

You have a good list of ingredients for a formulation targeting mature, combination skin with concerns like deep wrinkles and sagging. Using an Aloe Vera Gel base is also a suitable choice for combination skin as it provides hydration without being too heavy.

Let's review the ingredients and the suggested adjustments:

Your Initial Ingredients

Many of the ingredients you listed are beneficial for anti-aging and overall skin health:

• Glucosamine (N-acetyl-D): Supports the skin barrier and can help with skin tone.
• Sea Kelp Extract: Provides moisture and soothing properties.
• Yeast Radiance: Offers moisturizing benefits and can help improve skin radiance.
• Vitamin B3 (Niacinamide): A versatile ingredient that strengthens the skin barrier, reduces inflammation, minimizes pores, and addresses fine lines and uneven tone.
• Repair Activator: Helps support the skin's natural repair processes, which is beneficial for aging skin.
• DMAE: Known for potential temporary skin firming effects, useful for sagging concerns.
• Gotu Kola (Centella Asiatica) Extract: Calming, supports healing, and may aid collagen production.
• Apple Stem Cell Extract: Provides antioxidant benefits and supports skin vitality.

These ingredients provide a solid foundation for addressing multiple signs of aging.

Adjustments and Additions

The advice you received is well-suited for combination skin and targeting deep wrinkles:

• Removing Vitamin B5 (Panthenol) and Snail Secretion: For combination skin that isn't particularly dry or sensitive, removing these highly moisturizing and soothing ingredients can result in a lighter, more comfortable texture in a gel base. If your skin doesn't need the extra hydration or calming effect, this is a reasonable adjustment.
• Adding Peptides: Incorporating peptides is an excellent way to specifically target deep wrinkles and improve firmness.
  • Matrixyl 3000 (Pal-GHK, Pal-GQPR) and Pep-coll (Palmitoyl tripeptide-5) are peptides known to stimulate collagen production, helping to reduce wrinkle depth and improve elasticity.
  • Argireline (Acetyl Hexapeptide-8) works by helping to relax muscle contractions, which can smooth out expression lines like nasolabial folds.

Combining a collagen-boosting peptide (like Matrixyl 3000 or Pep-coll) with Argireline provides a powerful approach to tackle both collagen loss and dynamic wrinkles.

Recommended Approach

For your formulation in an Aloe Vera Gel base targeting mature, combination skin with deep wrinkles and sagging, a strong combination would include:

• Glucosamine (N-acetyl-D)
• Sea Kelp Extract
• Yeast Radiance
• Vitamin B3 (Niacinamide)
• Repair Activator
• DMAE
• Gotu Kola (Centella Asiatica) Extract
• Apple Stem Cell Extract
• Matrixyl 3000 or Pep-coll
• Argireline

You can choose to exclude Vitamin B5 and Snail Secretion if you prefer a lighter feel suitable for combination skin and don't require their specific moisturizing or soothing benefits. Adding the recommended peptides will significantly enhance the formula's ability to address deep wrinkles and improve skin firmness.