Solubility and Stability of MSH White in Cream and Toner
Question
What are the solubility and stability characteristics of MSH White™ (Undecylenoyl phenylalanine) when dissolved in alcohol and added to existing cream or toner bases? Specifically, will it precipitate, what alcohol ratio and heat are needed for dissolution, and is this method suitable for incorporating into finished products?
Answer
Information regarding MSH White™ solubility
Based on the properties of MSH White™ (Undecylenoyl phenylalanine):
Dissolving in alcohol and adding to a finished cream base: MSH White™ is soluble in oil and alcohol with heat. When adding an alcohol solution to a finished cream base (which is an emulsion of oil and water), there is a possibility that the MSH White™ may precipitate over time, especially if the alcohol evaporates or the cream base composition is not suitable to maintain its solubility or dispersion. The recommended method for incorporating MSH White™ is to dissolve it in the oil phase of the formulation using heat (around 80°C) before emulsifying.
Dissolving in alcohol and adding to water or toner: MSH White™ is not readily soluble in water at typical pH levels (it is soluble in high pH water >8). If dissolved in alcohol and added to a water-based product like a toner (which usually has a pH below 8), it is highly likely to precipitate out of the solution as the alcohol dilutes or evaporates.
Ratio of alcohol to MSH White for dissolution: The product information does not specify a required ratio of alcohol to MSH White™ for dissolution. It only states that it is soluble in alcohol with heat.
Heat requirement for dissolving in alcohol: Yes, heat is required. MSH White™ can be dissolved in alcohol at a temperature of at least 60°C.
Given your objective to add to existing products, achieving a stable solution without precipitation might be challenging, particularly with water-based toners. The most reliable method is to incorporate MSH White™ during the manufacturing process by dissolving it in the oil phase with heat.
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