Solubility Issue with B3-Boost™ (Picolinamide) at 3% Concentration

Asked by: aonchanika On: May 24, 2025 Product Type: Cosmetics

Question

I am trying to dissolve B3-Boost™ (Picolinamide) at a concentration of 3% in 12% butylene glycol, but I encountered precipitation and incomplete dissolution.

I would like to know:

  • What is the recommended method for dissolving B3-Boost™ (Picolinamide)?
  • What solvent or co-solvent should be used?
  • What percentage of the solvent/co-solvent should be used to achieve complete dissolution at 3% concentration?

Answer

Solubility of B3-Boost™ (Picolinamide)

Based on the product information for B3-Boost™ (Picolinamide), the recommended usage rate is 0.1-1%. While it is soluble in glycols like butylene glycol, using a concentration higher than the recommended rate, such as 3%, can lead to solubility issues and precipitation.

To achieve a clear solution, it is recommended to use B3-Boost™ (Picolinamide) within its recommended concentration range of 0.1-1%. If you need to use a higher concentration, you would likely require a significantly larger amount of butylene glycol or explore other solvents, but solubility at 3% is not guaranteed based on the standard product specifications which are optimized for the 0.1-1% range.

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