Solubility of Perfect-A 99 in Water-Based Serum

Regarding mixing Perfect-A 99 (Hydroxypinacolone Retinoate 99%), which is supplied dissolved in Ethoxydiglycol and other glycols, directly into your Vitamin C E Ferulic serum:

Perfect-A 99 is a form of Hydroxypinacolone Retinoate that is primarily soluble in glycols and oils. Your Vitamin C E Ferulic serum is predominantly water-based. While your serum does contain some compatible solvents like Ethoxydiglycol and Propylene Glycol, the high water content means that directly adding the Perfect-A 99 solution is unlikely to result in a clear, stable solution.

You will likely encounter solubility issues, such as the mixture becoming cloudy or the Perfect-A 99 separating over time, because the retinoid and its primary solvents are not miscible with a large amount of water.

Recommendation

For a water-based serum like yours, it would be more suitable to use a form of Hydroxypinacolone Retinoate that is designed to disperse well in water. Consider using:

• Perfect-A 10 (Hydroxypinacolone Retinoate, Liquid): This is a 10% liquid solution of HPR in Dimethyl Isosorbide, which is designed to disperse in water-based formulas.
• Perfect-A Nano (Hydroxypinacolone Retinoate Encapsulation): This is an encapsulated powder form of HPR that can be dispersed directly in the water phase of a formulation.

These alternative forms are formulated to integrate more effectively into systems with high water content, providing better stability and clarity compared to adding the oil/glycol soluble Perfect-A 99 directly.