Solubilizing Palmitoyl Glycine in Water-Based Serum with Syn-Ake Compatibility

To incorporate PalGLY (Palmitoyl Glycine) into a water-based serum while ensuring compatibility with (Syn-Ake eq.) Dipeptide Diaminobutyroyl Benzylamide Diacetate, here is the recommended approach:

1. Best Choice for Dissolving PalGLY: Free Solve™

Free Solve™ (PEG-Free Solubilizer) is the most suitable option for your formula.

• Why Free Solve™?: PalGLY is an oil-soluble peptide in powder form. To create a clear water-based serum, it must be dissolved in a solubilizer first. Syn-Ake eq. has a strict incompatibility with PEG-40 Hydrogenated Castor Oil. Since Flora Solve™ Clear has a proprietary composition, there is a risk it contains PEG-40 HCO. Free Solve™ is explicitly PEG-free (based on Oleths), making it the safer choice to maintain the stability and efficacy of the Syn-Ake peptide.
• How to mix:
  1. Mix PalGLY with Free Solve™ (you can also include your essential oils or fragrance in this step).
  2. Gently heat the mixture to approximately 60-80°C while stirring until the PalGLY powder is completely dissolved and the liquid is clear.
  3. Slowly add this mixture into your water phase while stirring.

2. Regarding Flora Solve™ Clear

While Flora Solve™ Clear is an excellent solubilizer for fragrances, its proprietary nature makes it difficult to guarantee compatibility with Syn-Ake's restriction against PEG-40 Hydrogenated Castor Oil. Using it may risk degrading the Syn-Ake peptide.

3. Regarding Propanediol

Propanediol (1,3-Propanediol) is a great humectant and solvent, but it is generally not sufficient on its own to solubilize PalGLY into a clear water-based serum. It can be included in the formula (typically 3-5%) to improve skin feel and boost preservation, but it should not replace the solubilizer (Free Solve™) for dissolving the PalGLY.

4. Compatibility & Formulation Summary

To ensure the stability of both peptides:

• pH Control: The final serum must have a pH between 3.5 and 6.5 for Syn-Ake to remain effective.
• Temperature: Add Syn-Ake eq. at the very end of the process, once the serum has cooled to below 40°C.
• Avoid Restricted Ingredients: Ensure your preservative system does not include Potassium Sorbate, Benzyl Alcohol, or Dehydroacetic Acid, as these are incompatible with Syn-Ake.