Spot Treatment Gel Formulation for Post-Acne Extraction

Subject: Re: Spot treatment gel after clogged acne extraction

Hello,

Thank you for sharing your proposed formula for a spot treatment gel after clogged acne extraction, aimed at reducing redness and preventing inflammation.

Based on your initial formula and the staff's feedback, here is a summary of the recommendations:

• Licochalcone A: Staff suggested increasing the concentration from 0.1% to 1%.
• Hi-Quercetin®: Your proposed concentration of 1% was not specifically commented on by staff, but it's a good ingredient for this purpose.
• nano silver Pure™: Staff suggested increasing the concentration from 0.5% to 1%.
• Vitamin B5 (Panthenol): Staff recommended adding this ingredient at 3% for its soothing and healing properties.
• Zinc PCA: Staff recommended adding this ingredient at 0.5-1.0% (suggesting 1%) to help with gel clarity (when using AnyGel) and promote wound healing.
• Any Gel (Dehydroxanthan Gum): Your proposed concentration of 1% was not specifically commented on for adjustment, but staff noted that adding an electrolyte like Zinc PCA can improve clarity.
• Preservative: Staff strongly recommended adding a preservative like Mild Preserved Eco at 1%. You mentioned your intention to use nano silver Pure™ as the preservative at 0.5% (or 1% as suggested by staff). Staff acknowledged this and advised ensuring proper dispersion if using nano silver for this purpose. While nano silver has antimicrobial properties, relying solely on it for broad-spectrum preservation might require careful validation. The staff's recommendation of Mild Preserved Eco is a standard approach for ensuring product stability against microbial growth.

Considering the staff's comprehensive suggestions for enhancing the gel's efficacy for post-extraction treatment (reducing redness, preventing inflammation, promoting healing), a revised formula incorporating their recommendations (including a dedicated preservative for stability) could look like this:

• Licochalcone A: 1%
• Hi-Quercetin®: 1%
• nano silver Pure™: 1%
• Vitamin B5 (Panthenol): 3%
• Zinc PCA: 1%
• Mild Preserved Eco: 1%
• Any Gel (Dehydroxanthan Gum): 1%
• Water: Balance to 100% (approx. 91%)

Alternatively, if you proceed with using nano silver Pure™ as your sole preservative, ensure it is sufficiently dispersed as advised by staff, and you might exclude the Mild Preserved Eco, adjusting the water percentage accordingly. However, using a dedicated preservative is generally recommended for product safety and shelf-life.

The ingredients recommended by staff (Licochalcone A, nano silver Pure™, Vitamin B5, Zinc PCA, Mild Preserved Eco) along with your initial choices (Hi-Quercetin®, Any Gel) appear suitable for the intended purpose of reducing redness, preventing inflammation, and aiding healing after acne extraction.

Relevant product IDs from this discussion include: 69, 358, 857, 1282, 111, 1001, 252.

We hope this summary and suggested formula are helpful!