Stability and Compatibility of L-Ascorbic Acid with Glutathione, Vitamin B3, and B6 in a Formula

Based on the staff's response regarding the formula containing Glutathione and Vitamin C (L-Ascorbic Acid):

• L-Ascorbic Acid Stability: For L-Ascorbic Acid to remain stable, the formula's pH must be maintained at approximately 3.0.
• Adding Other Ingredients:
  • Ingredients that do not affect the pH (such as oil-soluble ingredients) can generally be added.
  • However, adding water-soluble ingredients, especially those with a relatively high pH, can increase the overall pH of the formula. If the pH rises above 3.0, the L-Ascorbic Acid will degrade more quickly.
• Specific Incompatibility: Vitamin B3 (Safe-B3 / Niacinamide) is explicitly mentioned as incompatible with L-Ascorbic Acid. Mixing them will cause both ingredients to degrade.
• Regarding Vitamin B6: Vitamin B6 is water-soluble. Based on the general rule provided by the staff, its compatibility depends on whether adding it significantly affects the formula's pH. If it causes the pH to rise above 3.0, it could destabilize the L-Ascorbic Acid.

In summary, while some ingredients might be added, it's crucial to consider their impact on the formula's pH to ensure L-Ascorbic Acid stability. Vitamin B3 (Safe-B3) should not be added at all. For Vitamin B6 and other water-soluble whitening agents, compatibility depends on maintaining the pH at 3.0.