Stability and Solubility of MSH White™ in a Formulation at pH 5.3
Question
Could you please review the following formula and advise on the stability of MSH White™ (Undecylenoyl Phenylalanine) at the final pH of 5.3?
Formula:
- Agua desionizada: 61.0% w/w
- Glicerina: 3.0% w/w
- Xanthan Gum: 0.7% w/w
- Sclerotium Gum: 0.2% w/w
- Ume Extract: 0.5% w/w
- Tranexamic Acid: 3.0% w/w
- Sodium Ascorbyl Phosphate: 5.0% w/w
- Niacinamida: 4.0% w/w
- 4-Butylresorcinol: 0.3% w/w
- MSH White™ (Undecylenoyl Phenylalanine): 1.0% w/w
- Pure-EGCG™ (Epigallocatechin-3-gallate): 0.5% w/w
- ActiveRelease™ Pterostilbene: 0.2% w/w
- Ectoine: 0.5% w/w
- Pomegranate Extract: 1.0% w/w
- CocoSilk™ (Coco-Caprylate/Caprate): 2.0% w/w
- Squalane: 2.0% w/w
- Baobab Seed Oil: 1.0% w/w
- Tocopherol (Vitamina E): 0.5% w/w
- Phytic Acid: 0.3% w/w
- EDTA Disódico: 0.05% w/w
- L-Arginina (solución 10 %): qs pH
- Phenoxyethanol: 1.0% w/w
- Caprylyl Glycol: 0.5% w/w
- Sodium Dehydroacetate: 0.3% w/w
- Leuconostoc/Radish Ferment Filtrate: 0.5% w/w
- Gluconolactona + Sodium Benzoate (Geogard): 0.25% + 0.25% w/w
- Rosemary Leaf Extract: 0.2% w/w
The final pH of the formula is 5.3.
Answer
Based on the product information for MSH White™ (Undecylenoyl Phenylalanine), it is soluble in water only when the pH is adjusted to be higher than 8. At acidic pH levels, such as 5.3, MSH White™ is not soluble in the water phase.
To ensure stability and proper incorporation of MSH White™ in your formula, you should dissolve it in the oil phase of your formulation using heat (at least 60°C, preferably 80°C as mentioned in the description for dissolving in oil). Alternatively, if incorporating into the water phase, the pH of the water phase must be adjusted to above 8 before adding MSH White™.
Given your formula's final pH of 5.3, incorporating MSH White™ directly into the water phase without pH adjustment or into the final mixture might lead to solubility and stability issues. It is recommended to dissolve MSH White™ in the oil phase with heat before combining phases.
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