Stabilizing Trans-Resveratrol and Related Ingredients

Regarding your questions about stabilizing Trans-Resveratrol and the use of synthetic stabilizing agents:

1. Stabilizing Trans-Resveratrol (Product ID 761): Yes, using stabilizing agents can help slow down the degradation of Trans-Resveratrol, which has low stability. In addition to antioxidants, using UV light absorbers is also necessary because Trans-Resveratrol is sensitive to light.

2. Safety of Synthetic Stabilizers (Product IDs 1333, 1332, 4306) with Penetration Enhancers: Ingredients like Protec™ UV (Benzotriazolyl Dodecyl p-Cresol, Product ID 1333), Protec™ OX (Pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, Product ID 1332), and Hydroxyacetophenone (Product ID 4306) are synthetic chemicals that have undergone safety testing by various national regulatory bodies, such as the Thai FDA (which references European FDA data). These tests include evaluations under conditions where skin absorption might be enhanced. Therefore, using these ingredients in formulations containing penetration enhancers is considered safe.

3. Hydroxyacetophenone (Product ID 4306) vs. Protec™ OX (Product ID 1332) for Antioxidation:

   • Protec™ OX (Product ID 1332) has clearer test results specifically demonstrating its antioxidation effects.
   • Hydroxyacetophenone (Product ID 4306) is often chosen by formulators for its multiple benefits. It acts as a preservative booster (allowing for a significant reduction in the amount of other preservatives needed), provides antioxidation effects, and offers skin soothing properties.

Choosing between them depends on the desired benefits for the formula. If the primary need is strong, proven antioxidation, Protec™ OX might be preferred. If multi-functional benefits including preservative boosting and soothing are also desired, Hydroxyacetophenone is a good option.