Understanding Myristyl Nicotinate Formulation and Hydrophilic Ointment

Based on the formulation method you linked and the clarification provided:

1. Myristyl Nicotinate (Pro-Niacin) Solubility in Propylene Glycol: Myristyl Nicotinate (referred to as Pro-Niacin in the staff reply) does not fully dissolve in Propylene Glycol. When you mix them according to the method, it creates a paste where the Myristyl Nicotinate powder is dispersed within the Propylene Glycol, rather than a clear solution. To properly incorporate it into a formulation, it needs to be mixed into a cream base that contains both water and oil phases, often with the application of heat to help disperse the powder evenly.

2. What is Hydrophilic Ointment? A hydrophilic ointment is a type of ointment base that is designed to absorb water. As explained by the staff, it is typically made by combining water with an ointment base, such as Petrolatum, using an emulsifier or Cream Maker. This combination allows the ointment base, which is normally oil-loving (lipophilic), to become 'hydrophilic' or water-loving, enabling it to mix with and incorporate water-soluble ingredients.