Understanding Tranexamic Acid in Skincare

Tranexamic Acid is a popular ingredient in skincare, primarily known for its skin brightening properties and ability to reduce the appearance of dark spots and blemishes, particularly those caused by sun exposure.

How it Works

Tranexamic Acid works by helping to reduce the formation of melanin pigment in the skin, which is responsible for dark spots and uneven skin tone.

Forms and Related Ingredients

Besides standard Tranexamic Acid, there are also enhanced versions available:

• TXC™ (Cetyl Tranexamate HCl): This form is designed for better absorption into the skin compared to standard Tranexamic Acid. It was developed by Chanel and is recognized as a Quasi-drug in Japan.
• Nano-TXA™ (Tranexamic Acid Nano Emulsion, Penetration Base): This is Tranexamic Acid delivered in a nano-emulsion form, which can significantly enhance its penetration into the skin. This base can also help improve the delivery of other water-soluble active ingredients.

Usage in Cosmetics

Tranexamic Acid is commonly used as a whitening agent in various cosmetic formulations such as creams, lotions, serums, and gels.

Usage Rate and Regulations

In many regions, including ASEAN countries, the use of Tranexamic Acid in cosmetics is permitted at concentrations of up to 3%. If a product contains more than 3%, it may need to be registered as a medication for treating melasma. It is generally advised not to use concentrations exceeding 5% as this may lead to skin irritation.

Potential Side Effects and Precautions

While generally well-tolerated, using high concentrations of Tranexamic Acid (above 5%) can potentially cause skin irritation. It should also be avoided around the eyes and lips.

Mixing Instructions (General)

• Standard Tranexamic Acid and Nano-TXA™ are typically mixed into the water phase of a formulation and can dissolve directly in water.
• TXC™ is soluble in glycols (like Propylene Glycol, Butylene Glycol) or oil, often requiring heat (60-80°C) to dissolve, and is not soluble in water.