Usage and Compatibility of GlyciWhite™ (Glycinamide HCL)

Based on your questions about "Z white (Zinc Glycinate)" and its use in cosmetic formulations, it appears you are referring to GlyciWhite™ (Glycinamide HCL). Here is information regarding its use and compatibility with the other ingredients you mentioned:

GlyciWhite™ (Glycinamide HCL) is a water-soluble ingredient known for its ability to counteract the melanin production process gently without causing irritation.

Compatibility with Other Ingredients

It is possible to combine GlyciWhite™ with many of the ingredients you listed in an emulsion-based formula, provided the overall pH and mixing requirements of each ingredient are met.

• Sym White (Phenylethyl Resorcinol) and Activated Resorcinol (4-Butyl Resorcinol) are typically oil-soluble and require specific pH ranges (4-5 for Sym White, 4.5-5.5 for Activated Resorcinol) and the inclusion of Disodium EDTA for stability. Activated Resorcinol should generally not be used with Alpha Arbutin as they have similar mechanisms, with Activated Resorcinol being more potent.
• Perfect-C (Ascorbyl Tetraisopalmitate) is oil-soluble and works best at pH 5.0-5.5, requiring Disodium EDTA if water is present.
• Ethyl Ascorbic Acid and Alpha Arbutin are water-soluble. Ethyl Ascorbic Acid prefers a pH of 3.5-6.0 and needs Disodium EDTA if water is present. Alpha Arbutin works best at pH 3.5-6.5 and should not be exposed to pH above 8.
• B3 (Niacinamide) is water-soluble and stable over a wide pH range (3-8, best at 4.0-7.0).
• Perfect-C and Ethyl Ascorbic Acid product information indicates they should not be used with Vitamin B3. Activated Resorcinol, however, is noted as compatible with Vitamin B3. Sym White is also generally considered compatible with Vitamin C and Niacinamide. When combining these, it is crucial to consider these specific compatibility notes.
• Information regarding the compatibility of Ume Extract with these ingredients is not available.

GlyciWhite™ itself is water-soluble and does not have specific incompatibility warnings listed with these ingredients, but the overall formulation must be stable and effective for all components.

Solubility and Mixing

GlyciWhite™ is soluble in water. It should be added to the water phase of your formulation. Avoid heating it above 60°C during the mixing process. It cannot be added at just any step if that step involves high heat or is the oil phase.

Need for Disodium EDTA

Based on the product information for GlyciWhite™, it does not explicitly state that Disodium EDTA is required for its stability. However, Disodium EDTA is recommended at 0.2% for the stability and to prevent discoloration of several other ingredients you mentioned, including Sym White, Activated Resorcinol, Perfect-C (if water is present), and Ethyl Ascorbic Acid (if water is present). Including 0.2% Disodium EDTA is generally beneficial in formulations containing water to chelate metal ions that can destabilize sensitive ingredients.

Usage Rate and Sensation

The recommended usage rate for GlyciWhite™ is 3-10%, with 5% being the typical recommended concentration for efficacy. Using it at 1% or 1.5% is below this recommended range.

Experiencing a tingling sensation at 1% and 1.5% is a personal skin reaction and can vary between individuals. While 1.5% might feel similar or slightly more tingly than 1%, both concentrations are below the level typically recommended for optimal results (3-5%). If the tingling is tolerable, using 1.5% might offer a marginal improvement over 1%, but for better efficacy, you might consider gradually increasing the concentration towards the 3-5% range if your skin can tolerate it. Always prioritize skin comfort.