Usage of ActiveProtec OX with Encapsulated Hydroxyphenyl Propamidobenzoic Acid
Question
Could you please advise on whether I would still need to add ActiveProtec OX to protect the formulation from oxidation if I use the encapsulated version of Hydroxyphenyl Propamidobenzoic Acid?
If yes, what would be the recommended level of ActiveProtec OX when the encapsulated Hydroxyphenyl Propamidobenzoic Acid is used at around 2%?
Answer
Even though ActiveRelease Oat™ (Hydroxyphenyl Propamidobenzoic Acid, Encapsulated) is encapsulated in Cyclodextrin to improve stability and solubility, it is still highly recommended to include an antioxidant/stabilizer like ActiveProtec™ OX in your formulation.
Why it is recommended:
Hydroxyphenyl Propamidobenzoic Acid is a phenolic compound (synthetic avenanthramide). Phenolic structures are naturally sensitive to oxidation, which can lead to discoloration (yellowing or browning) and a decrease in efficacy over time when exposed to light, air, or heat. While encapsulation provides a protective barrier, it does not completely eliminate the risk of oxidation within the entire product matrix during its shelf life.
Recommended Usage Levels:
When using ActiveRelease Oat™ at a concentration of 2%, the recommended level for ActiveProtec™ OX is:
- 0.1% - 0.2%: This range is generally sufficient to protect the active ingredient from oxidation and prevent discoloration in most standard formulations.
Important Considerations:
- pH Level: The formulation must maintain a pH higher than 4.0. ActiveProtec™ OX is not stable in highly acidic environments (pH < 4).
- Electrolytes: ActiveProtec™ OX contains electrolytes. If your formula uses thickeners that are sensitive to salt (such as certain carbomers), you may need to adjust the thickener type or concentration.
- Odor Management: ActiveProtec™ OX has a slight characteristic odor. If this affects your final product, you can use Odor-Kill™ at a 1:1 ratio with the stabilizer (e.g., 0.1% Odor-Kill™ for 0.1% ActiveProtec™ OX) to neutralize the scent.
- Mixing: ActiveProtec™ OX is water-soluble and can be mixed directly into the water phase.
Using this combination will ensure that your product remains stable, effective, and maintains its intended color throughout its shelf life.
Related Products Mentioned
Odor-Kill™