Usage Rate and Solubility of Penetration Enhancers
Question
I would like to inquire about the usage rate and water solubility of several substances, specifically whether they function as penetration enhancers. The substances I am asking about include Polysorbate 20, Tetrahydropiperine (Natural Penetration Enhancer), and Hexa-B3™ (Hexyl Nicotinate), among others.
Answer
Penetration Enhancer Usage Rates and Solubility
Regarding your question about the usage rates of the attached substances as penetration enhancers and their water solubility, based on the information available:
All the substances you inquired about are water-soluble, as confirmed by the staff.
For specific penetration enhancers found:
- Tetrahydropiperine (Natural Penetration Enhancer): Can be used at a rate of 0.01%. It is soluble in water, Propylene Glycol, Fractionated Coconut Oil, and Glycerin.
- Hexa-B3™ (Hexyl Nicotinate): Can be used at a rate of 0.1-1%. It is soluble in MCT Oil, Isopropyl Myristate, and other polar esters (oil and polar solvents).
Please note that Polysorbate 20 is not classified as a penetration enhancer.
You can find complete information, including solubility and usage rates, on the product pages on the website.
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