Using AcnePLEX™ with Serums Containing Charged Gel Makers

Regarding your question about using AcnePLEX™ and a serum containing a charged Gel Maker like Pro Polymer / Acrylate Crosspolymer sequentially:

The instruction not to use AcnePLEX™ with charged ingredients like Pro Polymer / Acrylate Crosspolymer applies primarily when formulating a single product. Mixing these ingredients directly in a concentrated formula can cause instability or undesirable changes in texture or efficacy due to charge interactions.

However, when applying finished serums sequentially onto the skin, the situation is different. The ingredients are diluted on the skin's surface, and the gel structure formed by the polymer in the second serum is already established. Applying a serum containing AcnePLEX™ followed by a serum containing Pro Polymer / Acrylate Crosspolymer is generally acceptable and unlikely to cause the same kind of severe incompatibility issues (like precipitation or complete loss of texture) that would occur during formulation.

Therefore, you can generally apply a serum containing AcnePLEX™ and a serum containing a charged Gel Maker like Pro Polymer / Acrylate Crosspolymer sequentially. You do not necessarily need to apply them at different times of the day.

As always, observe how your skin reacts to the combination.