Using Ceramide NG with Cholesterol and Alternatives

Yes, it is recommended to use Ceramide NG (Ceramide 2) in combination with Cholesterol and Phytosphingosine. This combination is designed to mimic the natural lipid structure of the skin barrier, which consists of Ceramides, Cholesterol, and Fatty Acids in an optimal ratio. Using these components together helps to effectively restore and strengthen the skin's protective barrier, improving hydration and reducing sensitivity.

This is similar to how Ceramide Complex (like CeraTouch) is often used, as these complexes are formulated to provide a blend of ceramides along with Cholesterol and Phytosphingosine for comprehensive skin barrier repair.

You are correct that pure Cholesterol has a very high melting point (around 150°C), which can make formulation difficult due to the high heat required for mixing.

Fortunately, there are alternative ingredients and pre-formulated complexes that can provide the benefits of this lipid combination without the high-heat requirement of pure Cholesterol:

• Pre-combined Ceramide Complexes: Products like Cera-Flux V and Cera-Flux VX are water-dispersible complexes that already contain a blend of ceramides (including Ceramide NG in Cera-Flux VX), Phytosphingosine, and Cholesterol. These are easier to incorporate into formulations, typically requiring heat up to 80°C.
• Liposomal Ceramide Complexes: Ceracare™ Liposome-3 is a liposomal complex containing ceramides, phosphatidylcholine, and phytosterols. It provides a skin-mimicking lipid structure that enhances barrier repair and is easily dispersed in water without high heat.
• Fatty Acid Component: While not a direct replacement for Cholesterol, remember that the optimal skin barrier lipid ratio also includes Fatty Acids. Ingredients like LipidSoft™ F (Ethyl Linoleate) or natural oils can serve as the fatty acid component in your formulation alongside ceramides and cholesterol (or a complex containing them).

In summary, while combining Ceramide NG with Cholesterol and Phytosphingosine is ideal for mimicking the skin barrier, you can use pre-formulated complexes like Cera-Flux V, Cera-Flux VX, or Ceracare™ Liposome-3 to achieve a similar beneficial effect without the difficulty of melting pure Cholesterol.