Hydroxypropyl-Beta-Cyclodextrin Usage

Regarding your question about using hydroxypropyl-beta-cyclodextrin to increase the stability of ingredients in a cream/gel formulation:

Cyclodextrin can encapsulate substances, which can increase their stability. However, research indicates that when ingredients are encapsulated by cyclodextrin, their absorption into the skin can be reduced. This means that while the ingredient might be more stable, its effectiveness on the skin could be lower because less of it is absorbed.

Cyclodextrin is more commonly used in applications where reduced or controlled absorption is desired, such as:

• Encapsulating fragrances for longer-lasting scent.
• Encapsulating ingredients like Salicylic Acid for controlled release to minimize irritation from rapid absorption.

For the list of ingredients you provided:

• Cell-Energy (Adenosine)
• Repair Activator (Bifida Ferment Lysate)
• Matrixyl 3000 (Palmitoyl Oligopeptide, Palmitoyl Tetrapeptide-7)
• Active Resveratrol
• AA2G (Ascorbyl Glucoside)
• Vitamin B5 (Panthenol)
• DMAE (Dimethylaminoethanol)
• 1,2-Hexanediol
• PE-1 Aqua
• Hydroxyethyl Cellulose

These ingredients are generally stable on their own and do not typically require additional modification with cyclodextrin for stability in a formulation.