Using Tranexamic Acid from Capsules for Topical Application

Using Tranexamic Acid powder from oral capsules for topical application on the face or arms is generally not recommended. While Tranexamic Acid is an effective ingredient for skin brightening and reducing blemishes when applied topically, the form found in oral capsules is intended for ingestion and may contain fillers or binders that are not suitable or safe for skin application.

Effectiveness: Topical vs. Oral Use

Topical application of cosmetic-grade Tranexamic Acid, such as Tranexamic Acid (Trans-White™), can be effective for treating localized skin concerns like melasma and dark spots by reducing melanin production. Its effectiveness depends heavily on the formulation, including concentration, pH, and the presence of penetration enhancers (like in Nano-TXA™).

Oral Tranexamic Acid is typically prescribed for more severe or widespread melasma and works systemically. The effectiveness of topical application from a capsule compared to oral intake is difficult to determine and likely less predictable due to the lack of proper cosmetic formulation.

Potential Side Effects

Topical application generally has fewer systemic side effects than oral ingestion. However, using non-cosmetic grade powder or improperly formulated solutions can lead to local skin irritation, redness, or dryness. Cosmetic-grade Tranexamic Acid (Trans-White™) is recommended for use at concentrations up to 3% in cosmetic products. Using concentrations above 5% may cause skin irritation and requires registration as a medicine.

Mixing Advice for Topical Use

It is strongly advised not to use the powder from oral capsules for topical application. For safe and effective topical use, it is best to use cosmetic-grade Tranexamic Acid (Trans-White™) powder.

To formulate with cosmetic-grade Tranexamic Acid (Trans-White™):

• It is soluble in water.
• Mix it into the water phase of your formulation.
• The final product should have a pH in the range of 3-8.
• Use at a concentration of up to 3% for cosmetic purposes.

Alternatively, products like TXC™ (Cetyl Tranexamate HCl) are derivatives designed for better skin absorption, although they have different solubility properties (soluble in glycol or oil, not water). Nano-TXA™ is a pre-dispersed nano-emulsion form that enhances penetration.

For best results and safety, use ingredients specifically manufactured for cosmetic application and follow recommended usage guidelines.