Using Pure-Biotin in Water Serum and Alternatives

How to Incorporate Pure-Biotin™ in Water-Based Serum and Alternatives

Pure-Biotin™ is a high-purity biotin powder that cannot be dissolved directly in typical water-based serum formulas. If you wish to use Pure-Biotin™ in a water formula, you must disperse it in the formula by blending, rather than dissolving it.

Additionally, normal Biotin is more soluble in water at a higher pH (above 6.5).

The usage instructions for Pure-Biotin™ also suggest adding about 3-7% Urea (5% recommended) to formulas containing Biotin to help transport Biotin into the skin more effectively. It is also recommended to add Triacetin at approximately 10% of the Urea amount (e.g., if using 5% Urea, use 0.5% Triacetin) to help control the formula's pH and prevent Urea degradation.

Regarding alternatives since Biotin Express™ is unavailable, MySkinRecipes offers interesting products:

• ActiveRelease™ Biotin: This is an encapsulated form of Biotin that can be dissolved directly in water without the pH limitations of normal Biotin. It is soluble from pH 3.5 upwards, and pH 4-5 is a range where the scalp can absorb Biotin much better. Dissolution can be accelerated by heating to 60 degrees Celsius.
• Biotinyl-GHK (Biotinoyl Tripeptide-1): This is a peptide linked with Biotin, available as a liquid that is easily soluble in water. It is known for its property of accelerating hair growth.

Therefore, if you want to use Pure-Biotin™ in a water-based serum, you must disperse it by blending and may consider using Urea and Triacetin together for improved efficacy and skin penetration. Alternatively, you can choose ActiveRelease™ Biotin or Biotinyl-GHK, which are more easily water-soluble alternatives.