Can Vitamin D3 be used in cream formulations?

While direct formulation of Vitamin D3 can be challenging due to stability, its precursor, 7-dehydrocholesterol (Pure Powder), is an excellent ingredient for cream formulations. This ingredient helps the skin create its own Vitamin D3.

Benefits of 7-dehydrocholesterol in creams:

• Improves skin hydration and barrier: Studies show it can increase skin hydration and reduce transepidermal water loss.
• Supports skin health: It aids in keratinocyte differentiation and antimicrobial peptide expression, contributing to overall barrier homeostasis.
• Anti-inflammatory and wound-healing effects: Through local Vitamin D metabolites, it can help reduce hyper-proliferation in conditions like psoriasis and accelerate wound healing.

Formulation Tips:

• Combine with antioxidants: Since 7-dehydrocholesterol can be pro-oxidant under UVA exposure, it is recommended to combine it with lipid-compatible antioxidants like tocopherol or silymarin.
• Stability: Encapsulate it in light-protected, oxygen-controlled delivery systems (e.g., liposomes, polymeric nanocapsules) to maintain stability.
• Usage Rate: The optimal concentration in creams ranges from 0.05% to 0.2%, with a general usage rate of 0.1-3%.
• Mixing: Mix into the oil phase of your formula, avoiding heat above 40°C.
• Storage: Store the raw material in a refrigerator at 6-8°C. Mixed cosmetics containing it should also be stored in the refrigerator.

This ingredient is suitable for moisturizers targeting sensitive skin, dry skin, and premature aging skin. You can find links to all mentioned products below this answer.