Ingredient Compatibility, Stability, and Precipitation in Low-Water Serum at pH 3.5

ถามโดย: jiralexk เมื่อ: August 16, 2016 ประเภทผลิตภัณฑ์: เครื่องสำอาง

คำถาม

I have a serum formulation with approximately 50% water content, targeting a pH of 3.5. The formula contains the following key ingredients:

  • Wild Yam Extract
  • Ferulic Acid (dissolved in Ethoxydiglycol)
  • Glutathione

I've observed precipitation/crystallization in the formula, and the staff has indicated potential long-term separation issues due to the low water content. Could you please explain:

  1. The compatibility and stability of these ingredients at pH 3.5?
  2. Why precipitation is occurring, especially considering the presence of Glutathione?
  3. How to properly mix Ferulic Acid (dissolved in Ethoxydiglycol) to avoid precipitation?
  4. Confirm if increasing the water content to at least 60% is necessary for stability and how it affects these ingredients?

คำตอบ

Ingredient Compatibility and Stability at pH 3.5

Based on your revised formula and the staff's feedback, here are the key points regarding ingredient compatibility and stability at a target pH of 3.5:

  • Wild Yam Extract: This ingredient's optimal pH range is 4-6.5. While it might degrade faster at pH 3.5, it should be acceptable for personal use within approximately 6 months.
  • Ferulic Acid: Ferulic Acid, even when dissolved in Ethoxydiglycol, is not directly soluble in water. Adding this mixture to the water phase will cause precipitation or crystallization.
  • Glutathione: Glutathione dissolves in water, but it can be slow. Gentle warming (50-60°C) can help. Your observation of precipitation when Glutathione was present was likely due to the Ferulic Acid's insolubility in water, not a direct incompatibility with Glutathione.
  • Formula Stability: With approximately 50% water content, the formula might not be stable long-term and could separate. The staff recommends increasing the water phase to at least 60% for better stability.

Correct Mixing Method for Ferulic Acid:

To prevent precipitation, dissolve Ferulic Acid in Ethoxydiglycol separately. Prepare your serum base (water phase with water-soluble ingredients like Glutathione, and oil phase). Add the Ferulic Acid/Ethoxydiglycol mixture to the finished serum base at the very end and mix thoroughly.

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