Using PE-1 Aqua and Glycols in Cream/Gel Formulas with LipidSoft

Hello,

Regarding your follow-up questions, the team would like to answer as follows:

1. If I want to make a skin cream formulation using LipidSoft instead of oil and Light Cream Maker to create the cream texture (but the formula does not contain oil-soluble active ingredients), can I still use PE-1 Aqua in the formula even without oil-soluble ingredients? This is because I want a cream texture.

   • Yes, you can use PE-1 Aqua (ID: 856) in the cream formula. This is because LipidSoft (ID: 391) is not an active ingredient that requires deep skin penetration. It functions similarly to natural oils, helping to reduce water loss and providing a good skin feel on the outer layer.

2. For formulas containing oil-soluble ingredients, which penetration enhancer is best, and which is good but cheaper?

   • Most oil-soluble active ingredients sold by the company are currently in a base that aids penetration, so no additional penetration enhancer is needed. For ingredients still sold as powder soluble in oil, the company plans to switch to liquid forms that are well-absorbed in the future.

3. If I include PE-1 Aqua in a cream or gel formula, can Ethoxydiglycol also be included?

   • If it is not necessary (e.g., if there is no other ingredient in the formula that requires Ethoxydiglycol (ID: 137) for dissolution), you should not include Ethoxydiglycol (ID: 137) together with PE-1 Aqua (ID: 856).

4. If I include PE-1 Aqua in a cream or gel formula, can Propylene Glycol and Butylene Glycol also be included?

   • Yes, they can be included, but not in large amounts. It is recommended not to exceed 5%. Based on experimental results, using PE-1 Aqua (ID: 856) together with Propylene Glycol (ID: 138) at a level of 3-5% can help increase penetration effectiveness. However, using too much will reduce effectiveness.

Hope this information is helpful.