often referred to as PT-1 or Pal-GHK, is a synthetic peptide that is commonly used in skincare products due to its Stimulates Collagen Production property

PurePEP™-PT1P is Pure Palmitoyl Tripeptide-1 Peptide Powder, with purity above 90%.

Palmitoyl Tripeptide-1, often referred to as PT-1 or Pal-GHK, is a synthetic peptide that is commonly used in skincare products. Here are some of its topical benefits:

Stimulates Collagen Production: Palmitoyl Tripeptide-1 is known to stimulate collagen synthesis in the skin. Collagen is a protein that helps maintain skin's firmness, elasticity, and overall youthfulness. By promoting collagen production, PT-1 can help improve skin texture and reduce the appearance of wrinkles and fine lines.

Enhances Skin Repair: This peptide has been shown to support skin repair processes. It can help improve the skin's ability to recover from damage caused by environmental stressors, UV radiation, and other factors that contribute to premature aging.

Firms and Tightens: By boosting collagen production, Palmitoyl Tripeptide-1 can contribute to firmer and tighter skin. This can lead to a more lifted appearance, particularly in areas prone to sagging, such as the cheeks and jawline.

Improves Skin Elasticity: Loss of skin elasticity is a common sign of aging. PT-1 can help improve skin elasticity by promoting collagen synthesis, leading to smoother and more supple skin.

Reduces Wrinkles and Fine Lines: One of the most notable benefits of Palmitoyl Tripeptide-1 is its ability to reduce the appearance of wrinkles and fine lines. By stimulating collagen production and supporting skin repair processes, PT-1 can help diminish the signs of aging, resulting in a smoother and more youthful complexion.

Hydrates the Skin: Palmitoyl Tripeptide-1 can also help enhance skin hydration by strengthening the skin barrier. A stronger barrier helps prevent moisture loss and maintains optimal hydration levels in the skin.

Test : 0.05% Pure Palmitoyl Tripeptide-1 Peptide Powder and 0.015% Pure Palmitoyl Tripeptide-1 Peptide Powder

Subjects : 0.05% 16 females; 0.015% 17 females
Sex : Female
Age range : 25 - 55years old
Test Site : Face;
Application Frequency : Twice a day after cleaning face in the morning and evening
Test Period : 8 weeks
Test Parameters : Determination of skin wrinkle difference is expressed in volume area and area ratio
Volume : used to indicate the size and depth of wrinkles
Area : used to indicate width and length of wrinkles
Area ratio : Used to indicate the ratio of wrinkles
Test condition : Temperature: 20℃- 25℃; Humidity: 40% - 60%

Study Design:

The aim of this study is to evaluate the effects of a cosmetic product over a period of 2, 4, and 8 weeks of application in female subjects.

Day 0:
1. Clean the face with water.
2. Review and complete the informed consent form.
3. Spend 15 minutes in a lab with controlled conditions: temperature between 20℃ and 25℃, humidity between 40% and 60%.
4. Assess skin wrinkles using VisioFace 1000D.
5. Take photos.

Day 14, 28, and 56:
1. Repeat the face-cleaning step.
2. Review and complete the informed consent form.
3. Spend 14 minutes in the lab with controlled conditions.
4. Assess skin wrinkles using VisioFace 1000D.
5. Take photos.

Method:

Skin Wrinkle Assessment:
Skin wrinkles (including canthus and eye bags) are measured using VisioFace 1000D. Wrinkle differences are expressed in volume, area, and area ratio:
- Volume: Indicates size and depth of wrinkles; lower values indicate shallower wrinkles.
- Area: Indicates width and length of wrinkles; lower values indicate smaller wrinkles.
- Area ratio: Indicates the ratio of wrinkles; lower values indicate better skin condition.

Performance Test:
Participants were selected from the Nanjing volunteer database based on the following criteria:
1. Healthy females.
2. Willing to cooperate with the study and maintain regular lifestyle habits.
3. Understanding of the study procedures and objectives, and provision of informed consent.
4. Agreement to discontinue use of any skincare products except the test product during the study.
5. Not currently participating in clinical trials at other research centers.
6. Agreement not to use cosmetics, medications, or health products that may affect the study results.

Exclusion Criteria:
Volunteers meeting any of the following conditions were excluded from the study:
1. Facial skin diseases that may interfere with the study results.
2. Allergic constitution.
3. Pregnancy or lactation.
4. Impaired heart, liver, or kidney function, or abnormal immune system.
5. Mental illness, endocrine disorders, or use of oral contraceptives.
6. Participation in self-assessment or medication use that may affect study results within 1 week prior to the study.
7. Use of beauty products orally or topically that may interfere with study results within 2 weeks.
8. Inability to cooperate with researchers.
9. Individuals deemed unsuitable for the study by the researchers.

Result:

Warning: to completely dissolve this type of peptide, it's highly recommended to homogenize it in the final step in emulsion formulation. It can't be added directly in water phase or oil phase. Do not use heat.

Use: for facial anti-aging products

How to mix: mix in emulsion

Utilization rate: 0.01-0.05%

Product characteristics: white powder

Solubility: can dissolve in emulsion (cannot dissolve in water)

Storage: can be stored at lowest possible temperature (below -20C is the best storage condition). The product has a minimum shelf life of 2 years.

INCI Name : Palmitoyl Tripeptide-1