Folinic acid calcium salt hydrate
98%
- Product Code: 64000
Alias:
Calcium folinate; N-[4-[(2-amino-5-formyl-1,4,5,6,7,8,-hexahydro-4-oxo-6-pteridinyl)methyl] Amino]benzoyl-L-glutamic acid calcium salt pentahydrate
CAS:
1492-18-8
| Molecular Weight: | 511.5(anhydrous basis) g./mol | Molecular Formula: | C₂₀H₂₁CaN₇O₇H₂O |
|---|---|---|---|
| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | room temperature |
Product Description:
Folinic acid calcium salt hydrate is widely used in medical treatments, particularly as an antidote for methotrexate toxicity. It helps rescue healthy cells from the harmful effects of methotrexate, a chemotherapy drug, by providing an alternative pathway for DNA synthesis.
In oncology, it is often combined with fluorouracil (5-FU) to enhance the effectiveness of chemotherapy in treating colorectal cancer. It works by stabilizing the binding of 5-FU to its target enzyme, improving the drug's ability to inhibit cancer cell growth.
This compound is also utilized in the treatment of folate deficiency, where it acts as a biologically active form of folic acid, supporting red blood cell production and preventing anemia. Additionally, it is used in leucovorin rescue therapy to mitigate the side effects of high-dose methotrexate in cancer patients.
In prenatal care, it is sometimes administered to reduce the risk of neural tube defects in developing fetuses, especially in women with a history of such conditions or those on certain medications that interfere with folate metabolism. Its role in supporting cellular repair and growth makes it a valuable component in various therapeutic applications.
Product Specification:
| Test | Specification |
|---|---|
| PURITYHPLC | 98 100% |
| WATER BY KARL FISCHER | 0 16% |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 1.000 | 10-20 days | $82.23 |
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| 5.000 | 10-20 days | $289.87 |
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| 25.000 | 10-20 days | $1,037.39 |
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Folinic acid calcium salt hydrate
Folinic acid calcium salt hydrate is widely used in medical treatments, particularly as an antidote for methotrexate toxicity. It helps rescue healthy cells from the harmful effects of methotrexate, a chemotherapy drug, by providing an alternative pathway for DNA synthesis.
In oncology, it is often combined with fluorouracil (5-FU) to enhance the effectiveness of chemotherapy in treating colorectal cancer. It works by stabilizing the binding of 5-FU to its target enzyme, improving the drug's ability to inhibit cancer cell growth.
This compound is also utilized in the treatment of folate deficiency, where it acts as a biologically active form of folic acid, supporting red blood cell production and preventing anemia. Additionally, it is used in leucovorin rescue therapy to mitigate the side effects of high-dose methotrexate in cancer patients.
In prenatal care, it is sometimes administered to reduce the risk of neural tube defects in developing fetuses, especially in women with a history of such conditions or those on certain medications that interfere with folate metabolism. Its role in supporting cellular repair and growth makes it a valuable component in various therapeutic applications.
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