Characterized by a positive charge (quaternary), making it able to stick on the skin well. It can therefore be used in wash-off formulas such as soap or shampoo. The substance will still be able to stick to the skin or hair. to have continuous disinfectant effects

Quaternium-73, Popularly called the trade name PIONIN (This product is not produced by the manufacturer PIONIN and is not related in any way to the manufacturer PIONIN)

Quaternium-73 has a distinctive feature: Characterized by a positive charge (quaternary), making it able to stick on the skin well. It can therefore be used in wash-off formulas such as soap or shampoo. The substance will still be able to stick to the skin or hair. to have continuous disinfectant effects

The research found that Quaternium-73 It is very effective in killing almost all kinds of bacteria. which includes acne (P.Acnes) where the usage rate MicroKill™ at 1% in the formula (or equal to Quaternium-73 0.001%) can kill more than 99% of germs.  

use MicroKill™ at 1% in the formula (or equal to Quaternium-73 0.001%)   is therefore sufficient To kill acne

Quaternium-73 Can withstand high heat (85 degrees) And can withstand a wide range of pH values, which are 2-12, so it can be used in all products. But there is a limitation on light. in which the formula is used must be protected from light, for example, the product is packaged in an opaque bottle  

Quaternium-73 high security The fault is tested with various high concentrations as follows.

Human body patch test ( human body, 0.2%, 48 hours ): negative

Initial skin irritation ( rabbit, 0.2%, 24 hours ): negative

Sustained skin irritation ( rabbit, 0.01%, 90 day ):negative

Eye irritation ( rabbit, 0.0007%, 24 hour ): negative

Skin sensitization ( Guinea pig, 0.2%, maximum test ): negative

Phototoxicity (rabbit, 0.2%): negative

Photosensitization (Guinea Pig, 0.2%, Adjuvant-Strip Method): negative

Induced gene mutation (10μg, Ames test, ±S9 mix): negative

Acute Toxicity LD 50 ( mouse )：325 mg/kg  

In addition, it was found that Quaternium-73 Can inhibit the formation of melanin (skin pigment) by

Quaternium-73 0.000003% Can inhibit melanin in vitro by 50%.

Quaternium-73 0.00001% Can inhibit melanin in vitro by 83%.

In summary Quaternium-73 Able to work in all areas To treat acne Both kill P.Acnes bacteria well and reduce scars caused by acne at the same time. Goes through the process of reducing melanin formation.

Use: for treatment products and prevent acne and dandruff

How to mix: Can be dissolved directly in oil. Avoid heat.

Usage rate: 0.01-0.1%

Product characteristics: yellow powder

Solubility: Can dissolve in oil

Storage: Can be stored at room temperature But close the bottle cap tightly. Then completely protected from sunlight or heat. The product has a minimum shelf life of 2 years.

INCI Name : Quarternium-73

Examples of products used Quarternium-73

Hiruscar Post Acne Gel for Acne Scar Scars & Dark Marks

DHC Micro Skin Water

Dr.Ci:Labo Ci water SprayMist

Dr.Ci:Labo ACNELESS MOISTURE GEL

FANCL Cleartune Skin Clear Lotion

ProvaMed Acne Spot GEL