researchers have identified that an increase in the rogue protein serpin b3 results in damage accumulation within the epidermis, adversely affecting the basement membrane and dermis. This type of damage, when repeated, accelerates the aging process of the skin

Discovery of a New Mechanism Accelerating Skin Aging
Development of Anti-Aging Ingredients to Combat the Negative Effects of Serpin b3

Researchers have identified that an increase in the rogue protein serpin b3 results in damage accumulation within the epidermis, adversely affecting the basement membrane and dermis. This type of damage, when repeated, accelerates the aging process of the skin. Further, it was discovered that the continuous use of SerpinBlock™ (Piperidinepropanoic acid), an amino acid derivative, at high concentrations is highly effective in mitigating skin aging. These findings pave the way for the development of skincare products aimed at promoting smooth, firm, and youthful skin.

Research Insights into Serpin b3

The skin serves as a crucial barrier, protecting the body from external factors. Healthy skin maintains this protective mechanism to ensure resilience and beauty. However, when this mechanism fails, the skin experiences "parakeratosis" (abnormal keratinization), leading to compromised barrier functionality. While this condition has been observed for some time, the cause of parakeratosis was elusive until now.

The research team at SerpinBlock™ made significant strides by identifying serpin b3 as the primary cause of parakeratosis. This breakthrough was shared at the 24th International Federation of Societies of Cosmetic Chemists (IFSCC) Conference in 2006, earning an Honorary Mention Award for Basic Research. Building on this discovery, researchers developed SerpinBlock™, demonstrating its efficacy in controlling serpin b3 production.

New Findings on Serpin b3

SerpinBlock™ has continued its dedication to uncovering the mechanisms behind skin aging. Recent findings include:

1. Serpin b3 is a critical factor in skin aging.
2. Elevated levels of serpin b3 damage the surface and stratum corneum, propagating this harm throughout the epidermis.
3. Damage caused by serpin b3 extends to the basement membrane and dermis, further accelerating skin aging.

It was revealed that increased serpin b3 disrupts the skin's self-defense system (apoptosis), preventing the removal of damaged cells. These damaged cells release harmful factors that perpetuate a cycle of damage, impacting neighboring cells and amplifying harm. This cascade weakens the structural integrity of the dermis and basement membrane, highlighting serpin b3 as a novel accelerator of skin aging.

Development of SerpinBlock™ for Anti-Aging

Focused research led to the development of SerpinBlock™ (Piperidinepropanoic acid), a highly concentrated ingredient proven to effectively control serpin b3 production. This breakthrough ingredient not only inhibits the harmful effects of serpin b3 but also rejuvenates damaged skin. Its potential applications in anti-aging skincare promise significant advancements in nurturing youthful, resilient skin.

Use: For anti-aging skincare

How to mix: Mix in water (water-phase), avoid heat.

Utilization rate: 0.5-1%

Product characteristics: white to off-white powder

Solubility: can dissolve in water

Storage: For long-term storage Store in a cool place, 6-8 degrees, do not expose to sunlight, heat, seal the lid tightly, at least 2 years old.

INCI Name : Piperidinepropionic acid

The ingredient is used in many Shiseido products:

SHISEIDO haku botanic science cushion compact
SHISEIDO Future Solution LX Concentrated Brightening Softener
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SHISEIDO Eye and Lip Contour Regenerating Cream
SHISEIDO Future Solutions LX Legendary Enmei Ultimate Luminance Serum
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SHISEIDO Future Solution LX Total Radiance Foundation SPF 20
SHISEIDO FUTURE SOLUTION LX
SHISEIDO Future Solution LX Universal Defense SPF50+ PA++++
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SHISEIDO Future Solution LX Concentrated Balancing Softener