Vitamin B6 Palmitate, is a derivative of vitamin B6 that is used in various topical formulations for its potential benefits

Pyridoxine tripalmitate is a lipophilic (fat‐soluble) ester derivative of pyridoxine (vitamin B6) that’s been formulated specifically for topical use. Its chemical modification—attaching three palmitate (fatty acid) chains—enhances its ability to integrate into the skin’s lipid barrier, potentially improving its stability and absorption compared to water‐soluble vitamin B6.

Below are some of the proposed topical benefits along with supporting research insights:

Enhanced Skin Barrier Function

• Mechanism: The lipophilic nature of pyridoxine tripalmitate allows it to interact effectively with the skin’s lipid layers. This can help reinforce the barrier function, which is crucial for retaining moisture and protecting against environmental aggressors.
• Research Insight: Studies on vitamin B6 derivatives in topical formulations suggest that such compounds may support barrier repair and improve overall skin hydration. 

Anti‐Inflammatory and Soothing Effects

• Mechanism: Vitamin B6 is known for its role in cellular metabolism and has been associated with modulating inflammatory responses. When delivered topically in a stabilized, lipophilic form, it may help reduce local inflammation and soothe irritated skin.
• Research Insight: Research published in dermatological journals has indicated that vitamin B6 derivatives can reduce markers of inflammation in skin models, suggesting benefits for conditions like mild acne, eczema, or general skin irritation. 

Antioxidant Protection

• Mechanism: Oxidative stress from UV exposure and environmental pollutants can damage skin cells and accelerate aging. Pyridoxine tripalmitate may contribute to the neutralization of free radicals, helping to protect skin cells from oxidative damage.
• Research Insight: While direct studies on pyridoxine tripalmitate are still emerging, the antioxidant properties of vitamin B6 in its various forms have been noted, which supports its potential role in mitigating oxidative stress in the skin. 

Sebum Regulation and Skin Metabolism

• Mechanism: Vitamin B6 plays a role in normal cellular function and metabolism, including that of the sebaceous glands. This can help in regulating sebum production, potentially benefiting acne‐prone or oily skin.
• Research Insight: Reviews of vitamin B6 derivatives have pointed to their capacity to balance skin sebum levels while promoting healthy skin cell turnover. 

Use: For skin care products

Mixing method: Mix in oil(oil-phase), Use heat of about 70-80C to speed up the dissolution

Usage rate: 1-5%

Product characteristics: White powder

Solubility: can dissolve in oil

Storage: For long term storage Store at room temperature Do not expose to sunlight, heat, seal the lid tightly, shelf life at least 2 years.

INCI Name : Pyridoxine Tripalmitate