Amsacrine hydrochloride
≥98% (HPLC)
- Product Code: 110807
Alias:
Amacridine hydrochloride, Amacridine, Amacridine, N-[4-(9-acridylamino)-3-methoxyphenyl]methylsulfonamide
CAS:
54301-15-4
| Molecular Weight: | 429.92 g./mol | Molecular Formula: | C₂₁H₁₉N₃O₃SHCl |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD07799963 | |
| Melting Point: | 197-199 °C(lit.) | Boiling Point: | |
| Density: | Storage Condition: | room temperature |
Product Description:
Amsacrine hydrochloride is primarily used in the treatment of acute leukemia, particularly acute myeloid leukemia (AML). It functions as an antineoplastic agent by intercalating into DNA, which disrupts the replication process and inhibits the growth of cancer cells. This compound is often administered intravenously in clinical settings and is typically part of combination chemotherapy regimens to enhance its efficacy. Its use is carefully monitored due to potential side effects, including myelosuppression and cardiotoxicity. Amsacrine hydrochloride has shown significant activity in inducing remission in patients with refractory or relapsed AML, making it a valuable option in oncology.
Product Specification:
| Test | Specification |
|---|---|
| Melting Point | 197-199 |
| Purity (HPLC) | 98-100 |
| Appearance | Red To Brown Powder |
| Infrared Spectrometry | Conforms To Structure |
| Solubility In 30% Ethanol | 4 Mg/Ml |
| Solubility In DMSO | 10 Mg/Ml |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.025 | 10-20 days | $17.70 |
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| 0.100 | 10-20 days | $47.70 |
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| 0.250 | 10-20 days | $75.91 |
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| 1.000 | 10-20 days | $240.02 |
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Amsacrine hydrochloride
Amsacrine hydrochloride is primarily used in the treatment of acute leukemia, particularly acute myeloid leukemia (AML). It functions as an antineoplastic agent by intercalating into DNA, which disrupts the replication process and inhibits the growth of cancer cells. This compound is often administered intravenously in clinical settings and is typically part of combination chemotherapy regimens to enhance its efficacy. Its use is carefully monitored due to potential side effects, including myelosuppression and cardiotoxicity. Amsacrine hydrochloride has shown significant activity in inducing remission in patients with refractory or relapsed AML, making it a valuable option in oncology.
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