Ko143 hydrate
98%
- Product Code: 110831
Alias:
Ko143 hydrate; Ko-143 hydrate
CAS:
461054-93-3
Properties:
DMSO: >10 mg/mL
| Molecular Weight: | 469.57 g./mol | Molecular Formula: | C₂₆H₃₅N₃O₅ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD19053160 | |
| Melting Point: | 147 ºC | Boiling Point: | 689.8±55.0 °C at 760 mmHg |
| Density: | 1.24 g/ml | Storage Condition: | -20°C, sealed, dry |
Product Description:
Ko143 hydrate is primarily used in research settings as a potent and selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2). It is extensively applied in studies focused on understanding drug resistance mechanisms in cancer therapy, particularly in overcoming multidrug resistance. Researchers utilize it to investigate the role of BCRP in the efflux of chemotherapeutic agents, which helps in developing strategies to enhance the efficacy of cancer treatments. Additionally, it is employed in pharmacokinetic studies to assess the impact of BCRP on drug absorption, distribution, and excretion. Its application also extends to stem cell research, where it aids in identifying and isolating stem cell populations based on BCRP expression.
Product Specification:
| Test | Specification |
|---|---|
| Purity (HPLC) | 98-100 |
| Appearance | White To Off-White Powder |
| Infrared Spectrometry | Conforms To Structure |
| Solubility | >10 Mg/Ml In DMSO |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.001 | 10-20 days | $102.99 |
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| 0.005 | 10-20 days | $315.21 |
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| 0.025 | 10-20 days | $1,079.34 |
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Ko143 hydrate
Ko143 hydrate is primarily used in research settings as a potent and selective inhibitor of the breast cancer resistance protein (BCRP/ABCG2). It is extensively applied in studies focused on understanding drug resistance mechanisms in cancer therapy, particularly in overcoming multidrug resistance. Researchers utilize it to investigate the role of BCRP in the efflux of chemotherapeutic agents, which helps in developing strategies to enhance the efficacy of cancer treatments. Additionally, it is employed in pharmacokinetic studies to assess the impact of BCRP on drug absorption, distribution, and excretion. Its application also extends to stem cell research, where it aids in identifying and isolating stem cell populations based on BCRP expression.
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