Tirapazamine
≥98%
- Product Code: 56216
CAS:
27314-97-2
| Molecular Weight: | 178.15 g./mol | Molecular Formula: | C₇H₆N₄O₂ |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD00132954 | |
| Melting Point: | 230°C(dec.)(lit.) | Boiling Point: | |
| Density: | Storage Condition: | 2-8°C |
Product Description:
Tirapazamine is primarily used in the field of oncology as a hypoxic cytotoxin, specifically targeting cancer cells that are in low-oxygen (hypoxic) environments. These hypoxic regions are common in solid tumors and are often resistant to conventional radiation therapy and chemotherapy. By selectively killing these oxygen-deprived cells, tirapazamine enhances the effectiveness of radiation treatment. It works by undergoing bioreduction in hypoxic conditions to form a toxic free radical that damages DNA, leading to cell death. This makes it a valuable adjunct in combination therapies, particularly for cancers like head and neck, lung, and cervical cancers, where hypoxia is a significant challenge. Its application is carefully monitored due to potential side effects, but it remains a promising agent in improving cancer treatment outcomes.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | Orange to dark orange-red solid |
| PURITY | 98 |
| MELTING POINT | 220-240 |
| SOLUBILITY | DMSO: 10 mg/mL, clear |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.050 | 10-20 days | $265.79 |
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| 0.250 | 10-20 days | $824.77 |
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| 1.000 | 10-20 days | $1,946.88 |
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Tirapazamine
Tirapazamine is primarily used in the field of oncology as a hypoxic cytotoxin, specifically targeting cancer cells that are in low-oxygen (hypoxic) environments. These hypoxic regions are common in solid tumors and are often resistant to conventional radiation therapy and chemotherapy. By selectively killing these oxygen-deprived cells, tirapazamine enhances the effectiveness of radiation treatment. It works by undergoing bioreduction in hypoxic conditions to form a toxic free radical that damages DNA, leading to cell death. This makes it a valuable adjunct in combination therapies, particularly for cancers like head and neck, lung, and cervical cancers, where hypoxia is a significant challenge. Its application is carefully monitored due to potential side effects, but it remains a promising agent in improving cancer treatment outcomes.
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