Nα-(2,4,6-Triisopropylbenzenesulfonyl)-O-(tert-butyldiphenylsilyl)-π-methyl-L-histidinol

98%

  • Product Code: 71260
  CAS:    787554-04-5
Molecular Weight: 660.01 g./mol Molecular Formula: C₃₈H₅₃N₃O₃SSi
EC Number: MDL Number:
Melting Point: 177 °C Boiling Point:
Density: Storage Condition: room temperature
Product Description: This chemical is primarily utilized in peptide synthesis as a protecting group for histidine residues. It helps to prevent unwanted side reactions during the coupling of amino acids, ensuring the accuracy and efficiency of peptide chain assembly. The tert-butyldiphenylsilyl group protects the hydroxyl moiety, while the triisopropylbenzenesulfonyl group shields the imidazole ring of histidine. This dual protection is particularly useful in complex peptide synthesis, where selective deprotection can be achieved without disrupting the overall structure. Its application is crucial in the production of bioactive peptides, pharmaceuticals, and research compounds where precise control over peptide assembly is required.
Product Specification:
Test Specification
Melting point 171 177?
PURITYHPLC 98 100%
PURITYWITH TOTAL NITROGEN 98 100%
SPECIFIC ROTATION A20DC1 CHCL3 4 6
INFRARED SPECTROMETRY Conforms to Structure
Sizes / Availability / Pricing:
Size (g) Availability Price Quantity
0.100 10-20 days $450.95
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Nα-(2,4,6-Triisopropylbenzenesulfonyl)-O-(tert-butyldiphenylsilyl)-π-methyl-L-histidinol
This chemical is primarily utilized in peptide synthesis as a protecting group for histidine residues. It helps to prevent unwanted side reactions during the coupling of amino acids, ensuring the accuracy and efficiency of peptide chain assembly. The tert-butyldiphenylsilyl group protects the hydroxyl moiety, while the triisopropylbenzenesulfonyl group shields the imidazole ring of histidine. This dual protection is particularly useful in complex peptide synthesis, where selective deprotection can be achieved without disrupting the overall structure. Its application is crucial in the production of bioactive peptides, pharmaceuticals, and research compounds where precise control over peptide assembly is required.
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