VE-821
≥98%
- Product Code: 77805
CAS:
1232410-49-9
| Molecular Weight: | 368.41 g./mol | Molecular Formula: | C₁₈H₁₆N₄O₃S |
|---|---|---|---|
| EC Number: | MDL Number: | MFCD19443686 | |
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C |
Product Description:
VE-821 is primarily utilized in research settings as a potent and selective inhibitor of ATR kinase, a key enzyme involved in the DNA damage response pathway. Its application is significant in studying the mechanisms of DNA repair and cellular responses to genotoxic stress. Researchers use VE-821 to investigate the role of ATR in cancer biology, as inhibiting ATR can sensitize cancer cells to DNA-damaging therapies like chemotherapy and radiation. This makes it a valuable tool for exploring potential combination therapies to enhance the efficacy of existing cancer treatments. Additionally, VE-821 aids in understanding the broader implications of ATR inhibition in normal cells, helping to assess the therapeutic window and potential side effects of targeting this pathway.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | White to Green to Beige Solid |
| NMR | Consistent with structure |
| PURITY | 98 100% |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.005 | 10-20 days | $37.67 |
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| 0.025 | 10-20 days | $104.47 |
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| 0.100 | 10-20 days | $350.58 |
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VE-821
VE-821 is primarily utilized in research settings as a potent and selective inhibitor of ATR kinase, a key enzyme involved in the DNA damage response pathway. Its application is significant in studying the mechanisms of DNA repair and cellular responses to genotoxic stress. Researchers use VE-821 to investigate the role of ATR in cancer biology, as inhibiting ATR can sensitize cancer cells to DNA-damaging therapies like chemotherapy and radiation. This makes it a valuable tool for exploring potential combination therapies to enhance the efficacy of existing cancer treatments. Additionally, VE-821 aids in understanding the broader implications of ATR inhibition in normal cells, helping to assess the therapeutic window and potential side effects of targeting this pathway.
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