N-Methyl-N-(trimethylsilyl)acetamide
>90%(GC)
- Product Code: 93727
Alias:
N-methyl-N-(trimethylsilyl)acetamide
CAS:
7449-74-3
| Molecular Weight: | 145.27 g./mol | Molecular Formula: | C₆H₁₅NOSi |
|---|---|---|---|
| EC Number: | 231-217-0 | MDL Number: | MFCD00040758 |
| Melting Point: | Boiling Point: | 159-161 °C(lit.) | |
| Density: | 0.904 g/mL at 20 °C(lit.) | Storage Condition: | 2~8°C, dry |
Product Description:
N-Methyl-N-(trimethylsilyl)acetamide is primarily used in organic synthesis as a silylating agent. It is particularly effective in protecting hydroxyl groups during complex chemical reactions, ensuring that these groups remain unaffected while other parts of the molecule undergo transformation. This chemical is also utilized in the preparation of silyl enol ethers, which are key intermediates in various organic reactions, including aldol condensations and Michael additions. Additionally, it plays a role in the synthesis of peptides and nucleotides, where it aids in the protection and deprotection of functional groups, facilitating the stepwise construction of these complex molecules. Its ability to act as a mild and selective silylating agent makes it valuable in the development of pharmaceuticals and fine chemicals.
Product Specification:
| Test | Specification |
|---|---|
| PurityGC | 97 100% |
| REFRACTIVE INDEX N20D | 1.438-1.441 |
| SPECIFIC GRAVITY 2020C | 0.904-0.906 |
| APPEARANCE | COLORLESS TO RED LIQUID |
| INFRARED SPECTRUM | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 1.000 | 10-20 days | $30.60 |
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| 5.000 | 10-20 days | $113.71 |
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N-Methyl-N-(trimethylsilyl)acetamide
N-Methyl-N-(trimethylsilyl)acetamide is primarily used in organic synthesis as a silylating agent. It is particularly effective in protecting hydroxyl groups during complex chemical reactions, ensuring that these groups remain unaffected while other parts of the molecule undergo transformation. This chemical is also utilized in the preparation of silyl enol ethers, which are key intermediates in various organic reactions, including aldol condensations and Michael additions. Additionally, it plays a role in the synthesis of peptides and nucleotides, where it aids in the protection and deprotection of functional groups, facilitating the stepwise construction of these complex molecules. Its ability to act as a mild and selective silylating agent makes it valuable in the development of pharmaceuticals and fine chemicals.
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