L-778123 Dihydrochloride
98%
- Product Code: 96782
CAS:
183499-56-1
| Molecular Weight: | 478.8 g./mol | Molecular Formula: | C₂₂H₂₀ClN₅O₂HCl |
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| Density: | Storage Condition: | 2-8°C |
Product Description:
L-778123 Dihydrochloride is primarily utilized in cancer research due to its role as a selective inhibitor of farnesyltransferase. This enzyme is crucial for the post-translational modification of proteins involved in cell signaling and growth, particularly the Ras protein family, which is often mutated in various cancers. By inhibiting farnesyltransferase, L-778123 Dihydrochloride disrupts the activation of Ras proteins, thereby hindering the proliferation and survival of cancer cells.
In preclinical studies, it has shown potential in reducing tumor growth, making it a valuable compound for investigating targeted cancer therapies. Researchers use it to explore the efficacy of farnesyltransferase inhibitors in treating cancers like pancreatic, lung, and colorectal cancer, where Ras mutations are prevalent. Additionally, it serves as a tool to study the molecular mechanisms of Ras signaling pathways and their role in oncogenesis. Its application extends to drug development, where it aids in the design of more effective and specific anticancer agents.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.005 | 10-20 days | €377.79 |
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L-778123 Dihydrochloride
L-778123 Dihydrochloride is primarily utilized in cancer research due to its role as a selective inhibitor of farnesyltransferase. This enzyme is crucial for the post-translational modification of proteins involved in cell signaling and growth, particularly the Ras protein family, which is often mutated in various cancers. By inhibiting farnesyltransferase, L-778123 Dihydrochloride disrupts the activation of Ras proteins, thereby hindering the proliferation and survival of cancer cells.
In preclinical studies, it has shown potential in reducing tumor growth, making it a valuable compound for investigating targeted cancer therapies. Researchers use it to explore the efficacy of farnesyltransferase inhibitors in treating cancers like pancreatic, lung, and colorectal cancer, where Ras mutations are prevalent. Additionally, it serves as a tool to study the molecular mechanisms of Ras signaling pathways and their role in oncogenesis. Its application extends to drug development, where it aids in the design of more effective and specific anticancer agents.
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