A 83-01
≥98%
- Product Code: 99319
Alias:
3-(6-methylpyridin-2-yl)-N-phenyl-4-(quinolin-4-yl)-1H-pyrazole-1-thiocarboxamide; 3-(6-methyl- 2-pyridyl)-N-phenyl-4-(4-quinolyl)-1H-pyrazole-1-carbothioamide; A83-01; 3-(6-methyl-2-pyridyl) -N-Phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide; A-83-01
CAS:
909910-43-6
| Molecular Weight: | 421.52 g./mol | Molecular Formula: | C₂₅H₁₉N₅S |
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| EC Number: | MDL Number: | ||
| Melting Point: | Boiling Point: | ||
| Density: | Storage Condition: | -20°C, away from light, moisture, airtight and dry |
Product Description:
A 83-01 is widely used in biological research as a potent inhibitor of the TGF-β type I receptor kinase, also known as ALK5. It plays a crucial role in studying cellular processes influenced by TGF-β signaling, such as cell differentiation, proliferation, and apoptosis. Researchers utilize it to investigate the mechanisms of fibrosis, cancer progression, and immune regulation. Additionally, A 83-01 is employed in the development of organoid cultures, particularly in maintaining stem cell pluripotency and promoting epithelial cell growth. Its ability to modulate TGF-β pathways makes it a valuable tool in both basic science and therapeutic discovery.
Product Specification:
| Test | Specification |
|---|---|
| APPEARANCE | White to Orange to Green powder to crystaline |
| PURITY | 97.5-100 |
| Infrared spectrum | Conforms to Structure |
| NMR | Conforms to Structure |
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.001 | 10-20 days | $108.49 |
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| 0.005 | 10-20 days | $248.62 |
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| 0.025 | 10-20 days | $796.58 |
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| 0.100 | 10-20 days | $2,309.39 |
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A 83-01
A 83-01 is widely used in biological research as a potent inhibitor of the TGF-β type I receptor kinase, also known as ALK5. It plays a crucial role in studying cellular processes influenced by TGF-β signaling, such as cell differentiation, proliferation, and apoptosis. Researchers utilize it to investigate the mechanisms of fibrosis, cancer progression, and immune regulation. Additionally, A 83-01 is employed in the development of organoid cultures, particularly in maintaining stem cell pluripotency and promoting epithelial cell growth. Its ability to modulate TGF-β pathways makes it a valuable tool in both basic science and therapeutic discovery.
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