Galactooligosaccharide (GOS)
- Product Code: 11185
Research has found that it can help promote the growth of bacteria that are beneficial to the skin and reduce the growth of bacteria that are harmful to the skin.
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| Test Name | Specification |
|---|---|
| Appearance | White or light yellow powder. Without visible impurities. |
| Taste and smell | Sweet soft and fresh, no odor |
| Galacto-Oligosaccharides content (on dry basis), % | 90 Min |
| Moisture, % | 5 Max |
| Ash (sulphate) | 0.3% Max |
| pH | 2.8-6.0 |
| Lead (Pb), mg/kg | 0.5 Max |
| Total Plate Count | 1000 CFU/g Max |
| Total Coliform | 10 CFU/g Max |
| Salmonella | Not detected |
| Staphylococcus aureus | Not detected |
Galactooligosaccharide (GOS) is a prebiotic that research has shown can help promote the growth of beneficial bacteria on the skin and reduce the growth of bacteria that are harmful to the skin.
List of research projects:
1. Prebiotic effect of galacto-oligosaccharides on the skin microbiota and determination of their diffusion properties International Journal of Cosmetic Science ( IF 2.416 ) Pub Date: 2022-04-15
Research has found that applying 5% to the skin can help increase the number of beneficial S. epidermidis bacteria and reduce the harmful S. aureus bacteria.
2. Inhibitory Effect of Galactooligosaccharide on Skin Pigmentation (Please see attached document)
Research has found that GOS can help reduce the formation of melanin, thus making the skin whiter and brighter.
| Research | Topical benefit & mechanistic highlight | Research |
|---|---|---|
| 1. Prebiotic microbiome re-balancing – boosts Staphylococcus epidermidis while suppressing S. aureus; GOS molecules stay on the skin surface ≥ 24 h (good residency) | 5 % w/w in Aristoflex® hydrogel or O/W gel-cream | Petrov A et al., Int J Cosmet Sci 44 (3): 309–319, 2022 |
| 2. Barrier & hydration improvement – 8-week facial serum RCT showed ↑ water-holding capacity and ↓ TEWL; concurrent rise in beneficial microbial diversity | 2 % GOS serum, twice daily, 60 healthy adults | Hong K-B et al., J. Personalised Med. 10 (3): 91, 2020 |
| 3. Wound-healing acceleration via keratinocyte activation – purified GOS (and whey-GOS fraction) up-regulate NF-κB/FOXO-1 signalling, speeding scratch-closure and boosting filaggrin/occludin | 0.5–2 % in vitro; points to 1–3 % hydrogel for dressings | Bergandi L et al., Nutrients 14 (14): 2888, 2022 |
| 4. Anti-pigmentation – GOS suppress tyrosinase-driven melanin in B16F10 cells and lower melanin index in an 8-week human trial | 1–3 % lotion (clinical); 100–400 µg mL⁻¹ in vitro | Suh M-G et al., Prev Nutr Food Sci 24 (3): 321–326, 2019 |
| 5. Anti-inflammatory calming – GOS-treated keratinocytes release less IL-6/IL-8 after UVB or LPS challenge, suggesting soothing potential for sensitive-skin lines | 0.5 % solution, HaCaT model | Data within Bergandi L 2022 & Petrov A 2022 reports |
Usage: Use in any skin care formula.
Mixing method: Mix in water (water-phase)
Usage rate: 3-5%
Product appearance: white powder
Solubility: Soluble in water.
Storage: Can be stored at room temperature, but close the bottle tightly and keep away from sunlight or heat. Do not expose to moisture. The product has a shelf life of at least 2 years from the date of manufacture.
INCI Name : Galactooligosaccharide
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Galactooligosaccharide (GOS)
Research has found that it can help promote the growth of bacteria that are beneficial to the skin and reduce the growth of bacteria that are harmful to the skin.
Galactooligosaccharide (GOS) is a prebiotic that research has shown can help promote the growth of beneficial bacteria on the skin and reduce the growth of bacteria that are harmful to the skin.
List of research projects:
1. Prebiotic effect of galacto-oligosaccharides on the skin microbiota and determination of their diffusion properties International Journal of Cosmetic Science ( IF 2.416 ) Pub Date: 2022-04-15
Research has found that applying 5% to the skin can help increase the number of beneficial S. epidermidis bacteria and reduce the harmful S. aureus bacteria.
2. Inhibitory Effect of Galactooligosaccharide on Skin Pigmentation (Please see attached document)
Research has found that GOS can help reduce the formation of melanin, thus making the skin whiter and brighter.
| Research | Topical benefit & mechanistic highlight | Research |
|---|---|---|
| 1. Prebiotic microbiome re-balancing – boosts Staphylococcus epidermidis while suppressing S. aureus; GOS molecules stay on the skin surface ≥ 24 h (good residency) | 5 % w/w in Aristoflex® hydrogel or O/W gel-cream | Petrov A et al., Int J Cosmet Sci 44 (3): 309–319, 2022 |
| 2. Barrier & hydration improvement – 8-week facial serum RCT showed ↑ water-holding capacity and ↓ TEWL; concurrent rise in beneficial microbial diversity | 2 % GOS serum, twice daily, 60 healthy adults | Hong K-B et al., J. Personalised Med. 10 (3): 91, 2020 |
| 3. Wound-healing acceleration via keratinocyte activation – purified GOS (and whey-GOS fraction) up-regulate NF-κB/FOXO-1 signalling, speeding scratch-closure and boosting filaggrin/occludin | 0.5–2 % in vitro; points to 1–3 % hydrogel for dressings | Bergandi L et al., Nutrients 14 (14): 2888, 2022 |
| 4. Anti-pigmentation – GOS suppress tyrosinase-driven melanin in B16F10 cells and lower melanin index in an 8-week human trial | 1–3 % lotion (clinical); 100–400 µg mL⁻¹ in vitro | Suh M-G et al., Prev Nutr Food Sci 24 (3): 321–326, 2019 |
| 5. Anti-inflammatory calming – GOS-treated keratinocytes release less IL-6/IL-8 after UVB or LPS challenge, suggesting soothing potential for sensitive-skin lines | 0.5 % solution, HaCaT model | Data within Bergandi L 2022 & Petrov A 2022 reports |
Usage: Use in any skin care formula.
Mixing method: Mix in water (water-phase)
Usage rate: 3-5%
Product appearance: white powder
Solubility: Soluble in water.
Storage: Can be stored at room temperature, but close the bottle tightly and keep away from sunlight or heat. Do not expose to moisture. The product has a shelf life of at least 2 years from the date of manufacture.
INCI Name : Galactooligosaccharide
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