GNE-617
≥99%
- Product Code: 100695
CAS:
1362154-70-8
| Molecular Weight: | 427.42 g./mol | Molecular Formula: | C₂₁H₁₅F₂N₃O₃S |
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| Density: | Storage Condition: | 2-8℃ |
Product Description:
GNE-617 is primarily utilized in the field of cancer research, particularly in the study of metabolic pathways in tumor cells. It functions as a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme crucial for the biosynthesis of nicotinamide adenine dinucleotide (NAD+). By inhibiting NAMPT, GNE-617 disrupts NAD+ production, leading to energy depletion and ultimately inducing cell death in cancer cells. This makes it a valuable tool for investigating the role of NAD+ metabolism in cancer progression and for exploring potential therapeutic strategies targeting metabolic vulnerabilities in tumors. Additionally, GNE-617 is used in preclinical studies to evaluate the efficacy of NAMPT inhibition in various cancer models, helping to identify potential biomarkers and optimize treatment regimens.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
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| 0.002 | 10-20 days | €315.56 |
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| 0.005 | 10-20 days | €469.18 |
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GNE-617
GNE-617 is primarily utilized in the field of cancer research, particularly in the study of metabolic pathways in tumor cells. It functions as a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme crucial for the biosynthesis of nicotinamide adenine dinucleotide (NAD+). By inhibiting NAMPT, GNE-617 disrupts NAD+ production, leading to energy depletion and ultimately inducing cell death in cancer cells. This makes it a valuable tool for investigating the role of NAD+ metabolism in cancer progression and for exploring potential therapeutic strategies targeting metabolic vulnerabilities in tumors. Additionally, GNE-617 is used in preclinical studies to evaluate the efficacy of NAMPT inhibition in various cancer models, helping to identify potential biomarkers and optimize treatment regimens.
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