Thalidomide-NH-PEG8-Ts
95%
- Product Code: 106472
CAS:
2488761-07-3
| Molecular Weight: | 779.85 g./mol | Molecular Formula: | C₃₆H₄₉N₃O₁₄S |
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| Density: | Storage Condition: | -20°C, dry, sealed |
Product Description:
Thalidomide-NH-PEG8-Ts is widely utilized in the field of targeted drug delivery and molecular biology research. Its structure, incorporating a polyethylene glycol (PEG) linker, enhances solubility and bioavailability, making it suitable for conjugating with various therapeutic agents. This compound is particularly valuable in the development of Proteolysis-Targeting Chimeras (PROTACs), where it facilitates the targeted degradation of specific proteins by recruiting E3 ubiquitin ligases. Additionally, its thalidomide moiety allows for the selective binding to cereblon, a key protein in the ubiquitin-proteasome system, enabling precise control over protein degradation pathways. This makes it a critical tool in cancer research, especially for targeting oncogenic proteins that are otherwise difficult to inhibit using traditional small-molecule drugs. Furthermore, its tosyl (Ts) group provides a reactive handle for further chemical modifications, allowing researchers to tailor the compound for specific applications in drug development and bioconjugation strategies.
Sizes / Availability / Pricing:
| Size (g) | Availability | Price | Quantity |
|---|---|---|---|
| 0.050 | 10-20 days | Ft436,351.37 |
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Thalidomide-NH-PEG8-Ts
Thalidomide-NH-PEG8-Ts is widely utilized in the field of targeted drug delivery and molecular biology research. Its structure, incorporating a polyethylene glycol (PEG) linker, enhances solubility and bioavailability, making it suitable for conjugating with various therapeutic agents. This compound is particularly valuable in the development of Proteolysis-Targeting Chimeras (PROTACs), where it facilitates the targeted degradation of specific proteins by recruiting E3 ubiquitin ligases. Additionally, its thalidomide moiety allows for the selective binding to cereblon, a key protein in the ubiquitin-proteasome system, enabling precise control over protein degradation pathways. This makes it a critical tool in cancer research, especially for targeting oncogenic proteins that are otherwise difficult to inhibit using traditional small-molecule drugs. Furthermore, its tosyl (Ts) group provides a reactive handle for further chemical modifications, allowing researchers to tailor the compound for specific applications in drug development and bioconjugation strategies.
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